Research progress on GlnR-mediated regulation in Actinomycetes

Bo Gao; Guoqiang Li; Dayong Gu; Jin Wang

doi:10.3389/fmicb.2023.1282523

Research progress on GlnR-mediated regulation in Actinomycetes

Front Microbiol. 2023 Nov 22:14:1282523. doi: 10.3389/fmicb.2023.1282523. eCollection 2023.

Authors

Bo Gao^{1

2}, Guoqiang Li³, Dayong Gu¹, Jin Wang¹

Affiliations

¹ Department of Laboratory Medicine, Shenzhen Key Laboratory of Medical Laboratory and Molecular Diagnostics, Shenzhen Institute of Translational Medicine, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, China.
² Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, National-Regional Key Technology Engineering Laboratory for Medical Ultrasound, School of Biomedical Engineering, Shenzhen University Medical School, Shenzhen, China.
³ College of Life Science, Northwest A&F University, Yangling, Shaanxi, China.

Abstract

This review constitutes a summary of current knowledge on GlnR, a global regulator, that assumes a critical function in the regulation of nitrogen metabolism of Actinomycetes. In cross-regulation with other regulators, GlnR was also shown to play a role in the regulation of carbon and phosphate metabolisms as well as of secondary metabolism. A description of the structure of the GlnR protein and of its binding sites in various genes promoters regions is also provided. This review thus provides a global understanding of the critical function played by GlnR in the regulation of primary and secondary metabolism in Actinomycetes.

Keywords: Actinomycetes; GlnR; cross-regulation; global regulator; metabolic regulation.

Publication types

Review

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was supported by the National Key Research and Development Program of China [No. 2022YFC2302700]; Guangdong Science and Technology Foundation [No. 2021A1515220084, No. 2022B1111020001]; Shenzhen Science and Technology Foundation [ZDSYS20210623092001003, GJHZ20200731095604013, No. 201906133000069, JCYJ20190809160001751, JCYJ20200109120205924]; Medical-Engineering Interdisciplinary Research Foundation of ShenZhen University.