Nanomaterials as therapeutic agents to modulate astrocyte-mediated inflammation in spinal cord injury

Wenqi Luo; Yueying Li; Chunyu Xiang; Toshimi Aizawa; Renrui Niu; Yiming Wang; Jianhui Zhao; Zeping Liu; Chaoyuan Li; Wanguo Liu; Rui Gu

doi:10.1016/j.mtbio.2023.100888

Nanomaterials as therapeutic agents to modulate astrocyte-mediated inflammation in spinal cord injury

Mater Today Bio. 2023 Nov 29:23:100888. doi: 10.1016/j.mtbio.2023.100888. eCollection 2023 Dec.

Authors

Affiliations

¹ Department of Orthopaedic Surgery, China-Japan Union Hospital of Jilin University, Changchun, 130033, PR China.
² Department of Hand and Foot Surgery, China-Japan Union Hospital of Jilin University, Changchun, 130033, PR China.
³ Department of Orthopedic Surgery, Tohoku University Graduate School of Medicine, Sendai, 980-8574, Japan.

Abstract

Promoting the recovery of neurological function in patients with traumatic spinal cord injury (TSCI) remains challenging. The balance between astrocyte-mediated neurotrophic and pro-inflammatory responses is critical for TSCI repair. Recently, the utilization of nanomaterials has been considerably explored in immunological reconstructive techniques that specifically target astrocyte-mediated inflammation, yielding positive outcomes. In this review, we aim to condense the present knowledge regarding the astrocyte-mediated inflammation following TSCI. We then review the various categories of nanomaterials utilized in the management of astrocyte-mediated inflammation in TSCI and conclude by summarizing their functions and advantages to offer novel insights for the advancement of effective clinical strategies targeting TSCI.

Keywords: Astrocyte; Inflammation; Nanomaterials; Spinal cord injury; Treatment.

Publication types

Review