Pregnancy in women with cystic fibrosis and diabetes: An audit of outcomes at two tertiary obstetric hospitals in Australia in the pre-cystic fibrosis transmembrane conductance regulator modulator era

Sarah J Davidson; Megan France; Leonie K Callaway; Karin Lust; Daniel Chambers; Peter Hopkins; Scott C Bell; Lucy Burr; Rebecca Keating; Helen L Barrett

doi:10.1177/1753495X221146342

Pregnancy in women with cystic fibrosis and diabetes: An audit of outcomes at two tertiary obstetric hospitals in Australia in the pre-cystic fibrosis transmembrane conductance regulator modulator era

Obstet Med. 2023 Dec;16(4):217-221. doi: 10.1177/1753495X221146342. Epub 2022 Dec 25.

Authors

Sarah J Davidson^{1

2}, Megan France³, Leonie K Callaway^{1

4}, Karin Lust^{1

4}, Daniel Chambers^{4

5}, Peter Hopkins^{4

5}, Scott C Bell^{3

4

6}, Lucy Burr^{4

7

8}, Rebecca Keating⁷, Helen L Barrett^{8

9}

Affiliations

¹ Women's & Newborn Services, Royal Brisbane & Women's Hospital, Herston, Australia.
² Duke University School of Medicine, Durham, NC, USA.
³ Thoracic Medicine, The Prince Charles Hospital, Chermside, Australia.
⁴ Faculty of Medicine, The University of Queensland, Herston, Australia.
⁵ Queensland Lung Transplant Program, The Prince Charles Hospital, Chermside, Australia.
⁶ Translational Research Institute, Woolloongabba, Australia.
⁷ Department of Respiratory Medicine, Mater Health Services, South Brisbane, Australia.
⁸ Mater Research Institute - The University of Queensland, South Brisbane, Australia.
⁹ Departments of Endocrinology and Obstetric Medicine, Mater Health Services, South Brisbane, Australia.

PMID: 38074210
PMCID: PMC10710202 (available on 2024-12-01)
DOI: 10.1177/1753495X221146342

Abstract

Background: Pregnancy in women with cystic fibrosis (CF) is becoming more common. Long-term metabolic issues such as diabetes are also becoming more common and have potentially important impacts on pregnancy outcomes. This study aimed to assess the impact of diabetes on pregnancy outcomes for women with CF.

Methods: We undertook a retrospective chart audit of pregnancies to women with CF at the two tertiary obstetric hospitals in Southeast Queensland associated with CF and transplant management clinics between 2006 and 2016.

Results: A total of 38 pregnancies among 26 women were identified. Four women (five pregnancies) had cystic fibrosis-related diabetes (CFRD) diagnosed prior to pregnancy, and 12 women (15 pregnancies) developed gestational diabetes (GDM) complicating pregnancy. CFRD and GDM were associated with higher rates of delivery complications, prematurity, and the need for neonatal intensive care unit admission.

Conclusion: Diabetes is common during pregnancy in women with CF and impacts pregnancy outcomes.

Keywords: Cystic fibrosis; cystic fibrosis-related diabetes; gestational diabetes; pregnancy.