Functioning and mechanisms of PTMs in renal diseases

Zhenzhen Liu; Jian Yang; Minghui Du; Wei Xin

doi:10.3389/fphar.2023.1238706

Functioning and mechanisms of PTMs in renal diseases

Front Pharmacol. 2023 Nov 21:14:1238706. doi: 10.3389/fphar.2023.1238706. eCollection 2023.

Authors

Zhenzhen Liu¹, Jian Yang¹, Minghui Du², Wei Xin^{1

3}

Affiliations

¹ Medical Science and Technology Innovation Center, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China.
² Biomedical Science College, Shandong First Medical University, Jinan, China.
³ Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China.

Abstract

Post-translational modifications (PTMs) are crucial epigenetic mechanisms that regulate various cellular biological processes. The use of mass spectrometry (MS)-proteomics has led to the discovery of numerous novel types of protein PTMs, such as acetylation, crotonylation, 2-hydroxyisobutyrylation, β-hydroxybutyrylation, protein propionylation and butyrylation, succinylation, malonylation, lactylation, and histone methylation. In this review, we specifically highlight the molecular mechanisms and roles of various histone and some non-histone PTMs in renal diseases, including diabetic kidney disease. PTMs exhibit diverse effects on renal diseases, which can be either protective or detrimental, depending on the specific type of protein PTMs and their respective targets. Different PTMs activate various signaling pathways in diverse renal pathological conditions, which could provide novel insights for studying epigenetic mechanisms and developing potential therapeutic strategies for renal diseases.

Keywords: acute kidney injury; diabetic kidney disease; histone modifications; post-translational modification; renal disease.

Publication types

Review

Grants and funding

This study was supported by the National Natural Science Foundation of China (81970427 and 81471007) and the Shandong Province Taishan Scholar Project (tsqn202211218).