Phytosynthesis of gold-198 nanoparticles for a potential therapeutic radio-photothermal agent

Sumandi Juliyanto; Ligwina Dita Pertiwi; Ahid Nurmanjaya; Anung Pujiyanto; Herlan Setiawan; Fernanto Rindiyantono; Abidin; Ahsanal Fikri; Amal Rezka Putra; Alfian Mahardika Forentin; Veronika Yulianti Susilo; Muhamad Basit Febrian; Rien Ritawidya; Yoki Yulizar

doi:10.1016/j.apradiso.2023.111141

Phytosynthesis of gold-198 nanoparticles for a potential therapeutic radio-photothermal agent

Appl Radiat Isot. 2024 Feb:204:111141. doi: 10.1016/j.apradiso.2023.111141. Epub 2023 Dec 7.

Authors

Affiliations

¹ Research Center for Radioisotope, Radiopharmaceutical, and Biodosimetry Technology, Research Organization for Nuclear Energy-National Research and Innovation Agency, BRIN, Puspiptek Area, South Tangerang, 15314, Indonesia; Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Indonesia, Depok, 16424, Indonesia. Electronic address: sumandi.juliyanto@sci.ui.ac.id.
² Research Center for Radioisotope, Radiopharmaceutical, and Biodosimetry Technology, Research Organization for Nuclear Energy-National Research and Innovation Agency, BRIN, Puspiptek Area, South Tangerang, 15314, Indonesia.
³ Research Center for Radioisotope, Radiopharmaceutical, and Biodosimetry Technology, Research Organization for Nuclear Energy-National Research and Innovation Agency, BRIN, Puspiptek Area, South Tangerang, 15314, Indonesia; Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Indonesia, Depok, 16424, Indonesia.
⁴ Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Indonesia, Depok, 16424, Indonesia.

PMID: 38071856
DOI: 10.1016/j.apradiso.2023.111141

Abstract

We produced spherical gold-198 nanoparticles with an average size of 41 nm, good stability, and high radiochemical purity for a promising single agent of radio-photothermal therapy using Curcuma longa rhizome extract as a reducing and capping agent. The combination of in vitro treatment using gold-198 nanoparticles and irradiation of 980 nm wavelength lasers with a power output of 2 W/cm² induced hyperthermia temperature and exhibited enhancement of the percentage dead on MDA-MB-123 cancer cells compared to gold-198 nanoparticles alone.

Keywords: Cancer cells; Characterization; Gold-198 nanoparticles; Phytosynthesis; Radio-photothermal therapy.

MeSH terms

Cell Line, Tumor
Gold
Gold Radioisotopes*
Metal Nanoparticles*
Nanoparticles*
Phototherapy / methods

Substances

Gold-198
Gold
Gold Radioisotopes