Role of ADAM and ADAMTS proteases in pathological tissue remodeling

Zhaoni Wang; Wanshan Li; Shixing Chen; Xiao Xiao Tang

doi:10.1038/s41420-023-01744-z

Role of ADAM and ADAMTS proteases in pathological tissue remodeling

Cell Death Discov. 2023 Dec 9;9(1):447. doi: 10.1038/s41420-023-01744-z.

Authors

Zhaoni Wang¹, Wanshan Li¹, Shixing Chen¹, Xiao Xiao Tang^{2

3}

Affiliations

¹ State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
² State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China. tangxiaoxiao@gird.cn.
³ Guangzhou Laboratory, Bio-island, Guangzhou, China. tangxiaoxiao@gird.cn.

Abstract

Pathological tissue remodeling is closely associated with the occurrence and aggravation of various diseases. A Disintegrin And Metalloproteinases (ADAM), as well as A Disintegrin And Metalloproteinase with ThromboSpondin motifs (ADAMTS), belong to zinc-dependent metalloproteinase superfamily, are involved in a range of pathological states, including cancer metastasis, inflammatory disorders, respiratory diseases and cardiovascular diseases. Mounting studies suggest that ADAM and ADAMTS proteases contribute to the development of tissue remodeling in various diseases, mainly through the regulation of cell proliferation, apoptosis, migration and extracellular matrix remodeling. This review focuses on the roles of ADAM and ADAMTS proteinases in diseases with pathological tissue remodeling, with particular emphasis on the molecular mechanisms through which ADAM and ADAMTS proteins mediate tissue remodeling. Some of these reported proteinases have defined protective or contributing roles in indicated diseases, while their underlying regulation is obscure. Future studies are warranted to better understand the catalytic and non-catalytic functions of ADAM and ADAMTS proteins, as well as to evaluate the efficacy of targeting these proteases in pathological tissue remodeling.

Publication types

Review