Shared gustatory sensor for acids and ammonium

Akiyuki Taruno

doi:10.1016/j.tins.2023.11.009

Shared gustatory sensor for acids and ammonium

Trends Neurosci. 2024 Mar;47(3):163-164. doi: 10.1016/j.tins.2023.11.009. Epub 2023 Dec 9.

Author

Akiyuki Taruno¹

Affiliation

¹ Department of Molecular Cell Physiology, Kyoto Prefectural University of Medicine, Kyoto, Japan. Electronic address: taruno@koto.kpu-m.ac.jp.

PMID: 38071122
DOI: 10.1016/j.tins.2023.11.009

Abstract

In a recent study, Liang, Wilson, and colleagues demonstrated that the H⁺-selective ion channel OTOP1, responsible for sour taste transduction, also functions as a gustatory sensor for ammonium in mice. Additionally, this research revealed a novel mode of channel activation by intracellular alkalinization, which is conserved across vertebrate species.

Keywords: NH(4)Cl; OTOP; alkali; ion channel; otopetrin; taste.

MeSH terms

Ammonium Compounds*
Animals
Ion Channels
Mice

Substances

Ammonium Compounds
Ion Channels

Abstract

MeSH terms

Substances

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