A New Microfluidic Device to Facilitate Functional Precision Medicine Assays

Albert Manzano-Muñoz; Jose Yeste; María A Ortega; Josep Samitier; Javier Ramón-Azcón; Joan Montero

doi:10.1007/978-1-0716-3593-3_8

A New Microfluidic Device to Facilitate Functional Precision Medicine Assays

Methods Mol Biol. 2024:2748:99-108. doi: 10.1007/978-1-0716-3593-3_8.

Authors

Albert Manzano-Muñoz^{1

2}, Jose Yeste³, María A Ortega^{3

4}, Josep Samitier^{1

5

6}, Javier Ramón-Azcón^#^{3

7}, Joan Montero^#^{8

9

10}

Affiliations

¹ Nanobioengineering Group, Institute for Bioengineering of Catalonia (IBEC), Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.
² Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universitat de Barcelona, Barcelona, Spain.
³ Biosensors for Bioengineering Group, Institute for Bioengineering of Catalonia (IBEC), Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.
⁴ Vitala Technologies, Barcelona, Spain.
⁵ Networking Biomedical Research Center in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Madrid, Spain.
⁶ Department of Electronics and Biomedical Engineering, Faculty of Physics, University of Barcelona, Barcelona, Spain.
⁷ Institució Catalana de Reserca i Estudis Avançats (ICREA), Barcelona, Spain.
⁸ Nanobioengineering Group, Institute for Bioengineering of Catalonia (IBEC), Barcelona Institute of Science and Technology (BIST), Barcelona, Spain. jmontero@ub.edu.
⁹ Networking Biomedical Research Center in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Madrid, Spain. jmontero@ub.edu.
¹⁰ Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universitat de Barcelona, Barcelona, Spain. jmontero@ub.edu.

^# Contributed equally.

PMID: 38070110
DOI: 10.1007/978-1-0716-3593-3_8

Abstract

Functional precision medicine (FPM) has emerged as a new approach to improve cancer treatment. Despite its potential, FPM assays present important limitations such as the number of cells and trained personnel required. To overcome these impediments, here we describe a novel microfluidic platform that can be used to perform FPM assays, optimizing the use of primary cancer cells and simplifying the process by using microfluidics to automatize the process.

Keywords: Cancer treatment; Functional assays; Microfluidics; Precision medicine.

MeSH terms

Biological Assay
Lab-On-A-Chip Devices
Microfluidics*
Precision Medicine*