Association between healthy dietary patterns and markers of oxidative stress in the Sister Study

Brittany Crawford; Susan E Steck; Dale P Sandler; Hazel B Nichols; Ginger L Milne; Yong-Moon Mark Park

doi:10.1007/s00394-023-03280-z

Association between healthy dietary patterns and markers of oxidative stress in the Sister Study

Eur J Nutr. 2024 Mar;63(2):485-499. doi: 10.1007/s00394-023-03280-z. Epub 2023 Dec 9.

Authors

Brittany Crawford¹, Susan E Steck^#², Dale P Sandler³, Hazel B Nichols⁴, Ginger L Milne⁵, Yong-Moon Mark Park^#^{6

7

8}

Affiliations

¹ Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, 915 Greene St. #456, Columbia, SC, 29208, USA.
² Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, 915 Greene St. #456, Columbia, SC, 29208, USA. stecks@mailbox.sc.edu.
³ Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.
⁴ Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA.
⁵ Division of Clinical Pharmacology, Vanderbilt University Medical Center, Nashville, TN, USA.
⁶ Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA. ypark@uams.edu.
⁷ Department of Epidemiology, Fay W. Boozman College of Public Health, University of Arkansas for Medical Sciences, 4301 W. Markham St., #820, Little Rock, AR, 72205, USA. ypark@uams.edu.
⁸ Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, Little Rock, AR, USA. ypark@uams.edu.

^# Contributed equally.

PMID: 38070016
DOI: 10.1007/s00394-023-03280-z

Abstract

Purpose: We assessed the cross-sectional association between healthy dietary patterns [alternate Mediterranean diet (aMED), Dietary Approaches to Stop Hypertension (DASH), alternative Healthy Eating Index (aHEI), and Healthy Eating Index 2015 (HEI-2015)] and urinary biomarkers of oxidative stress.

Methods: Between 2003 and 2009, the Sister Study enrolled 50,884 breast cancer-free US women aged 35 to 74 (non-Hispanic White, 83.7%). Data were analyzed for 844 premenopausal and 454 postmenopausal women who had urine samples analyzed for F₂-isoprostanes and non-missing covariate data. Food frequency questionnaire responses were used to calculate dietary pattern scores. Concentrations of 8-iso-prostaglandin F_2α (8-iso-PGF_2α) and its metabolite (8-iso-PGF_2α-M) were measured in urine samples by GC/MS for premenopausal women and LC/MS for postmenopausal women. Multivariable linear regression models were used to estimate associations between aMED, DASH, aHEI, and HEI-2015 and urinary F₂-isoprostanes by menopausal status. Effect modification by sociodemographic, lifestyle, and clinical characteristics was also evaluated.

Results: Among premenopausal women, the four dietary indices were inversely associated with 8-iso-PGF_2α (aMED β_Q4vsQ1: - 0.17, 95% CI - 0.27, - 0.08; DASH β_Q4vsQ1: - 0.18, 95% CI - 0.28, - 0.08; aHEI β_Q4vsQ1: - 0.20, 95% CI - 0.30, - 0.10; HEI-2015 β_Q4vsQ1: - 0.19, 95% CI - 0.29, - 0.10). In contrast, inverse associations with 8-iso-PGF_2α-M were found for the continuous aMED, aHEI, and HEI-2015. Associations between dietary indices and 8-iso-PGF_2α were generally stronger among younger women, women with lower income, and women with higher BMI. Similar results were observed among postmenopausal women, though only the continuous DASH and aHEI models were statistically significant.

Conclusion: Healthy dietary patterns were associated with lower levels of oxidative stress.

Keywords: Diet; Dietary patterns; F2-isoprostanes; Menopause; Oxidative stress.

MeSH terms

Cross-Sectional Studies
Diet
Diet, Mediterranean*
Dietary Patterns*
F2-Isoprostanes
Female
Humans
Oxidative Stress
Prospective Studies

Substances

F2-Isoprostanes

Abstract

MeSH terms

Substances

Grants and funding