Lichen planus after COVID-19 infection and vaccination

Wafaa Saleh; Hamad Alharbi; Sijia Yue; Rui P Fernandes

doi:10.1111/odi.14834

Lichen planus after COVID-19 infection and vaccination

Oral Dis. 2023 Dec 8. doi: 10.1111/odi.14834. Online ahead of print.

Authors

Wafaa Saleh¹, Hamad Alharbi², Sijia Yue³, Rui P Fernandes⁴

Affiliations

¹ Oral Medicine, Periodontology, Diagnosis and Oral Radiology Department, Faculty of Dentistry, Mansoura University, Mansoura, Egypt.
² Department of Oral and Maxillofacial Surgery, King Abdulaziz University, Jeddah, Saudi Arabia.
³ Department of Biostatistics, University of Florida, Gainesville, Florida, USA.
⁴ Department of Oral and Maxillofacial Surgery, Division of Head and Neck Oncologic Surgery and Microvascular Reconstruction, College of Medicine, University of Florida, Jacksonville, Florida, USA.

PMID: 38069546
DOI: 10.1111/odi.14834

Abstract

Background: Lichen planus is one of the common adverse reactions after COVID-19 infection and vaccination. Despite it being reported in several case reports, the literature including a large sample of the studied population is lacking. The current study was performed to assess the risk of LP after COVID-19 infection as well as COVID-19 vaccination.

Methods: The current study was designed as a retrospective cross-sectional hospital-based study of registered patients at the University of Florida (UF) health centers. The diagnoses of LP, COVID-19 infection, and COVID-19 vaccines were detected. The logistic regression model was used to assess the risk of developing LP after COVID-19 infection and vaccination.

Results: A total hospital patient of 684,110 attended UF Health centers were included in this study. 181 patients reported LP after COVID-19 vaccination and 24 patients developed LP after COVID-19 infection. The risk of developing LP after COVID-19 vaccination was 1.573 while the risk of developing LP after COVID-19 infection was 1.143.

Conclusion: The odds of getting LP after COVID-19 vaccination are significantly developed. The current study showed that COVID-19 infection and vaccination are associated with LP. So, healthcare practitioners should be aware of this reaction for rapid recognition and treatment.

Keywords: COVID-19; COVID-19 vaccine; lichen planus.