Role of the Insulin-like Growth Factor (IGF) Axis in Diseases

Claire M Perks

doi:10.3390/ijms242316969

Role of the Insulin-like Growth Factor (IGF) Axis in Diseases

Int J Mol Sci. 2023 Nov 30;24(23):16969. doi: 10.3390/ijms242316969.

Author

Claire M Perks¹

Affiliation

¹ Cancer Endocrinology Group, Bristol Medical School, Translational Health Sciences, Learning & Research Building, Southmead Hospital, Bristol BS105NB, UK.

Abstract

The insulin-like growth factor axis is a multifaceted, complex system that comprises two ligands, IGF-I and IGF-II, receptors (IGF-1R, IGF-IIR, insulin receptor isoforms IR-A and B, and hybrid receptors) six high affinity IGF-binding proteins (IGFBPs 1-6), and IGFBP proteases [...].

Publication types

Editorial

MeSH terms

Insulin-Like Growth Factor Binding Protein 6 / metabolism
Insulin-Like Growth Factor Binding Proteins / metabolism
Insulin-Like Growth Factor I / metabolism
Insulin-Like Growth Factor II* / genetics
Insulin-Like Growth Factor II* / metabolism
Protein Binding

Substances

Insulin-Like Growth Factor II
Insulin-Like Growth Factor I
Insulin-Like Growth Factor Binding Proteins
Insulin-Like Growth Factor Binding Protein 6

Grants and funding

This research received no external funding.