Iridium-Catalysed Transfer Hydrogenation of 1,8-Naphthyridine with Indoline: Access to Functionalized N-Heteroarenes

Changjian Zhou; Jiahao Zhang; Yuqing Fu; Chunlian Chen; He Zhao

doi:10.3390/molecules28237886

Iridium-Catalysed Transfer Hydrogenation of 1,8-Naphthyridine with Indoline: Access to Functionalized N-Heteroarenes

Molecules. 2023 Dec 1;28(23):7886. doi: 10.3390/molecules28237886.

Authors

Changjian Zhou¹, Jiahao Zhang¹, Yuqing Fu¹, Chunlian Chen², He Zhao¹

Affiliations

¹ School of Chemistry and Chemical Engineering, Yancheng Institute of Technology, Yancheng 224051, China.
² Key Lab of Functional Molecular Engineering of Guangdong Province, School of Chemistry & Chemical Engineering, South China University of Technology, Guangzhou 510640, China.

Abstract

An iridium-catalysed hydrogen transfer strategy, enabling straightforward access to tetrahydro pyridine derivatives from aryl-1,8-naphthyridines and indolines, was developed. This method proceeds with unprecedented synthetic effectiveness including high step-economic fashion together with the advantages of having no by-product and no need for external high-pressure H₂ gas, offering an important basis for the transformation of 1,8-naphthyridines and indolines into functionalized products.

Keywords: 1,8-naphthyridines; N-heteroarenes; hydrogen transfer strategy; indolines.

Grants and funding

JGKT23_C085； KYCX23_3469； No. xjr2019007；No. xjr2023031/2023 Jiangsu Degree and Postgraduate Education Teaching Reform project；2023 Jiangsu Graduate Research and Practice Innovation plan； School-level Research projects of Yancheng Institute of Technology