Transition-Metal-Free One-Pot Synthesis of Fused Benzofuranamines and Benzo[ b]thiophenamines

Ran Liu; Lili Lv; Bingchuan Yang; Ziyi Gu; Chenglong Li; Xueyan Lv; Chengcheng Ding; Xianqiang Huang; Dong Yuan

doi:10.3390/molecules28237738

Transition-Metal-Free One-Pot Synthesis of Fused Benzofuranamines and Benzo[ b]thiophenamines

Molecules. 2023 Nov 23;28(23):7738. doi: 10.3390/molecules28237738.

Authors

Ran Liu¹, Lili Lv², Bingchuan Yang^{1

3

4

5}, Ziyi Gu¹, Chenglong Li⁶, Xueyan Lv⁴, Chengcheng Ding⁴, Xianqiang Huang¹, Dong Yuan³

Affiliations

¹ School of Chemistry and Chemical Engineering, Liaocheng University, Liaocheng 252000, China.
² China Petroleum Planning and Engineering Institute, Dongying 257237, China.
³ College of Chemistry and Chemical Engineering, Qilu Normal University, Jinan 250013, China.
⁴ School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, China.
⁵ The Department of Chemistry, University of South Florida, 4202 East Fowler Avenue, Tampa, FL 33620, USA.
⁶ Shandong Weijiao Holding Group Co., Ltd., Weifang 262404, China.

Abstract

A series of benzofuran and benzo[b]thiophen derivatives was synthesized via a transition-metal-free one-pot process at room temperature. This one-pot protocol enables the synthesis of compounds with high reaction efficiency, mild conditions, simple methods, and a wide-ranging substrate scope. Regioselective five-membered heterocycles were constructed in good-to-excellent yields.

Keywords: C-C coupling; benzo[b]thiophenamines; benzofuranamines; one-pot synthesis; transition metal-free.

Grants and funding

CXCY2023105, S202210447044, 202210447015/National Innovation and Entrepreneurship Training Program for College Students