Clinical and prognostic significance of CD27 and CD44 expression patterns in Egyptian pediatric patients with B-precursor acute lymphoblastic leukemia

Asmaa Abobakr; Randa A Osman; Mohamed A M Kamal; Sayed Abed Abdelhameed; Hagar H Ismail; Mahmoud M Kamel; Khalaf F Alsharif; Nema R Hamad

doi:10.1016/j.htct.2023.10.003

Clinical and prognostic significance of CD27 and CD44 expression patterns in Egyptian pediatric patients with B-precursor acute lymphoblastic leukemia

Hematol Transfus Cell Ther. 2023 Dec 6:S2531-1379(23)02592-0. doi: 10.1016/j.htct.2023.10.003. Online ahead of print.

Authors

Asmaa Abobakr¹, Randa A Osman¹, Mohamed A M Kamal², Sayed Abed Abdelhameed³, Hagar H Ismail⁴, Mahmoud M Kamel⁵, Khalaf F Alsharif⁶, Nema R Hamad⁷

Affiliations

¹ National Cancer Institute, Cairo University, Egypt.
² El Hussein Hospital, Al-Azhar University, Egypt.
³ National Cancer Institute, Cairo University, Cairo, Egypt.
⁴ College of Medicine, University of Illinois, Chicago, Chicago, IL, USA.
⁵ National Cancer Institute, Cairo University, Egypt. Electronic address: mahmoud.kamel@nci.cu.edu.eg.
⁶ Department of Clinical Laboratory Sciences , College of Applied Medical Sciences, Taif University, Taif 21944, Saudi Arabia.
⁷ National Institute of Urology & Nephrology, Cairo, Egypt.

PMID: 38065726
DOI: 10.1016/j.htct.2023.10.003

Abstract

Introduction: The expression pattern of CD27 and CD44 was found to correlate with the differentiation stages of B cell precursors, which were known to be involved in a variety of immunological responses.

Aim of the study: This study aimed to determine the biological significance of CD27 and CD44 expression in patients with B-precursor acute lymphoblastic leukemia (B-ALL), as well as their association with standard prognostic factors and therapeutic response.

Patients and methods: This case-control study included 60 pediatric patients newly diagnosed with B-ALL and 30 pediatric controls. The patient CD27 and CD44 levels were measured using the Beckman Coulter Navios Flow Cytometer.

Results: Most malignant cells (91.6 %) expressed CD44, but only 50 % of the patients had CD27 expressed. The positive CD 44 expression was associated with unfavorable prognostic markers, including a decrease.

Keywords: BCP-ALL; CD27; CD44; MRD; TEL/AM.