RBM39: A druggable metabolic sensor linking RNA splicing, transcriptional regulation, and metabolic reprogramming in cancer

Hector C Keun; Anke Nijhuis

doi:10.1016/j.molcel.2023.11.012

RBM39: A druggable metabolic sensor linking RNA splicing, transcriptional regulation, and metabolic reprogramming in cancer

Mol Cell. 2023 Dec 7;83(23):4202-4204. doi: 10.1016/j.molcel.2023.11.012.

Authors

Hector C Keun¹, Anke Nijhuis²

Affiliations

¹ Department of Surgery & Cancer, Imperial College London, London, UK. Electronic address: h.keun@imperial.ac.uk.
² Department of Surgery & Cancer, Imperial College London, London, UK.

PMID: 38065060
DOI: 10.1016/j.molcel.2023.11.012

Abstract

In a recent issue of Cell, Mossmann et al.¹ describe a novel role for an emerging cancer target, RNA-binding motif protein 39, as a metabolic sensor of the conditionally essential amino acid arginine.

MeSH terms

Alternative Splicing
Gene Expression Regulation
Humans
Neoplasms* / genetics
RNA Splicing
RNA-Binding Proteins* / metabolism

Substances

RNA-Binding Proteins
HCC1 autoantigen