Recent advances in the mechanism of hydrogen sulfide in wound healing in diabetes

Fengze Yang; Wenjie Zhong; Shengyuan Pan; Yue Wang; Qingyue Xiao; Xiang Gao

doi:10.1016/j.bbrc.2023.149343

Recent advances in the mechanism of hydrogen sulfide in wound healing in diabetes

Biochem Biophys Res Commun. 2024 Jan 15:692:149343. doi: 10.1016/j.bbrc.2023.149343. Epub 2023 Dec 3.

Authors

Fengze Yang¹, Wenjie Zhong², Shengyuan Pan³, Yue Wang⁴, Qingyue Xiao⁵, Xiang Gao⁶

Affiliations

¹ College of Stomatology, Chongqing Medical University, Chongqing, 401147, China; Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences, Chongqing, 401147, China; Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing, 401147, China. Electronic address: 2021120678@stu.cqmu.edu.cn.
² College of Stomatology, Chongqing Medical University, Chongqing, 401147, China; Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences, Chongqing, 401147, China; Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing, 401147, China. Electronic address: wjzhong94@hospital.cqmu.edu.cn.
³ College of Stomatology, Chongqing Medical University, Chongqing, 401147, China; Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences, Chongqing, 401147, China; Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing, 401147, China. Electronic address: 2023140361@stu.cqmu.edu.cn.
⁴ College of Stomatology, Chongqing Medical University, Chongqing, 401147, China; Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences, Chongqing, 401147, China; Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing, 401147, China. Electronic address: wangyue031@stu.cqmu.edu.cn.
⁵ College of Stomatology, Chongqing Medical University, Chongqing, 401147, China; Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences, Chongqing, 401147, China; Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing, 401147, China. Electronic address: 5501492@hospital.cqmu.edu.cn.
⁶ College of Stomatology, Chongqing Medical University, Chongqing, 401147, China; Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences, Chongqing, 401147, China; Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing, 401147, China. Electronic address: xiangg@hospital.cqmu.edu.cn.

PMID: 38065000
DOI: 10.1016/j.bbrc.2023.149343

Abstract

Wound healing difficulties in diabetes continue to be a clinical challenge, posing a considerable burden to patients and society. Recently, exploration of the mechanism of wound healing and associated treatment options in diabetes has become topical. Of note, the positive role of hydrogen sulfide in promoting wound healing has been demonstrated in recent studies. Hydrogen sulfide is a confirmed gas transmitter in mammals, playing an essential role in pathology and physiology. This review describes the mechanism underlying the role of hydrogen sulfide in the promotion of diabetic wound healing and the potential for hydrogen sulfide supplementation as a therapeutic application.

Keywords: Diabetes; Hydrogen sulfide; Review; Wound healing.

Publication types

Review

MeSH terms

Animals
Diabetes Mellitus* / drug therapy
Humans
Hydrogen Sulfide* / pharmacology
Mammals
Wound Healing / physiology

Substances

Hydrogen Sulfide