Lung cancer is one of the malignant tumors with the highest incidence and mortality rate in China, and its occurrence and development mechanism and treatment methods are the current research focuses. In recent years, the emergence of drugs targeting various tumor driver genes has significantly improved patients' survival and quality of life, setting off a wave of research on new therapeutic targets. Among them, long non-coding RNA (lncRNA) plays a crucial role in the malignant behavior of tumors, which has attracted widespread attention. Shown by a large number of studies, partial members of lncRNA small nucleolar RNA host gene (SNHG) family are aberrantly expressed in many maliglant tumors including non-small cell lung cancer (NSCLC) and participate in cell proliferation, invasion and migration, which may act as a new diagnostic and prognostic biomarker and can be a therapeutic target of NSCLC. In this review, we comprehensively summarize and explore the recent investigation of SNHGs in NSCLC in order to provide new ideas for the diagnosis and treatment of NSCLC. .
【中文题目：LncRNA SNHGs调控非小细胞肺癌的 生物学行为研究进展】 【中文摘要：肺癌是我国发病率和死亡率最高的恶性肿瘤之一，其发生发展机制及治疗手段是当前研究的热点。近年来，针对各种肿瘤驱动基因的分子靶向药物的出现显著提高了肺癌患者的生存率及生活质量，掀起了一波研究新型治疗靶标的热潮。其中长链非编码RNA（long non-coding RNA, lncRNA）在肿瘤的恶性行为中发挥了至关重要的作用，引起了人们的广泛关注。研究表明，lncRNA小核仁RNA宿主基因（small nucleolar RNA host gene, SNHG）家族部分成员在非小细胞肺癌（non-small cell lung cancer, NSCLC）等多种肿瘤组织中异常表达，参与肿瘤细胞的增殖、侵袭和转移等生物学过程，可能是NSCLC的诊断和预后的生物标志物，以及潜在的治疗新靶点。在这篇综述中，我们总结并探讨了SNHGs在NSCLC中的最新研究进展，以期为NSCLC的诊断及治疗提供新思路。 】 【中文关键词：长链非编码RNA；小核仁RNA宿主基因；肺肿瘤】.
Keywords: Long non-coding RNA; Lung neoplasms; Small nucleolar RNA host gene.