Rapid and directly interpretable antimicrobial susceptibility profiling by continuous microvolume-electroanalysis of ferricyanide-mediated bacterial respiration

Chem Commun (Camb). 2024 Jan 2;60(3):308-311. doi: 10.1039/d3cc04683d.

Abstract

We present a novel method for the electroanalysis of potassium ferricyanide-mediated bacterial electron transport, to rapidly assess viability and construct interpretable antimicrobial susceptibility profiles. Electrochemical minimum inhibitory concentrations (ecMICs) became determinable with a high correlation to the results from conventional assays.

MeSH terms

  • Anti-Bacterial Agents / pharmacology
  • Anti-Infective Agents*
  • Bacteria*
  • Electron Transport
  • Ferricyanides / pharmacology
  • Microbial Sensitivity Tests

Substances

  • hexacyanoferrate III
  • Ferricyanides
  • Anti-Infective Agents
  • Anti-Bacterial Agents