Research progress on the role of orphan receptor GPR139 in neuropsychiatric behaviours

Rumin Zhang; Jing Chen

doi:10.1016/j.ejphar.2023.176150

Research progress on the role of orphan receptor GPR139 in neuropsychiatric behaviours

Eur J Pharmacol. 2023 Dec 5:960:176150. doi: 10.1016/j.ejphar.2023.176150. Epub 2023 Oct 28.

Authors

Rumin Zhang¹, Jing Chen²

Affiliations

¹ Neurobiology Key Laboratory of Jining Medical University, Jining, 272067, China; School of Mental Health, Jining Medical University, Jining, 272067, China.
² Neurobiology Key Laboratory of Jining Medical University, Jining, 272067, China; School of Mental Health, Jining Medical University, Jining, 272067, China; Division of Biomedical Sciences, Warwick Medical School, University of Warwick, Coventry, CV47AL, UK. Electronic address: Jing.Chen@warwick.ac.uk.

PMID: 38059447
DOI: 10.1016/j.ejphar.2023.176150

Abstract

The study of orphan G protein-coupled receptors (GPCRs) holds much promise for increasing our understanding of neuropsychiatric diseases and for the development of new therapeutic strategies for these diseases. GPR139 is an orphan GPCR expressed in the central nervous system, especially in areas of the brain that control movement, motivation, and reward, and those that regulate neuropsychiatric behaviour. This review provides information about the discovery, tissue expression, signal transduction pathways, and physiological functions of GPR139, as well as how GPR139 interacts with other GPCRs, which form heteromeric complexes that affect their pharmacology and function. We also discuss the utility and therapeutic potential of ligands that target GPR139, including the pharmacological properties of reported agonists and antagonists. Finally, we highlight the pathologic role of GPR139 in neuropsychiatric behaviour and its potential as a therapeutic target in neuropsychiatric disorders.

Keywords: GPCR; GPR139; Neuropsychiatric behaviour; Orphan receptor; Signal transduction pathways.

Publication types

Review

MeSH terms

Receptors, G-Protein-Coupled* / metabolism
Signal Transduction*

Substances

Receptors, G-Protein-Coupled