Distinct Histone H3 Lysine 27 Modifications Dictate Different Outcomes of Gene Transcription

Tsuyoshi Konuma; Ming-Ming Zhou

doi:10.1016/j.jmb.2023.168376

Distinct Histone H3 Lysine 27 Modifications Dictate Different Outcomes of Gene Transcription

J Mol Biol. 2024 Apr 1;436(7):168376. doi: 10.1016/j.jmb.2023.168376. Epub 2023 Dec 4.

Authors

Tsuyoshi Konuma¹, Ming-Ming Zhou²

Affiliations

¹ Graduate School of Medical Life Science, Yokohama 230-0045, Japan; School of Science, Yokohama City University, Yokohama 230-0045, Japan.
² Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address: ming-ming.zhou@mssm.edu.

PMID: 38056822
DOI: 10.1016/j.jmb.2023.168376

Abstract

Site-specific histone modifications have long been recognized to play an important role in directing gene transcription in chromatin in biology of health and disease. However, concrete illustration of how different histone modifications in a site-specific manner dictate gene transcription outcomes, as postulated in the influential "Histone code hypothesis", introduced by Allis and colleagues in 2000, has been lacking. In this review, we summarize our latest understanding of the dynamic regulation of gene transcriptional activation, silence, and repression in chromatin that is directed distinctively by histone H3 lysine 27 acetylation, methylation, and crotonylation, respectively. This represents a special example of a long-anticipated verification of the "Histone code hypothesis."

Keywords: chromatin biology; gene transcription; histone modifications.

Publication types

Review

MeSH terms

Acetylation
Chromatin / genetics
Chromatin / metabolism
Histones* / genetics
Histones* / metabolism
Lysine* / genetics
Lysine* / metabolism
Protein Domains
Transcription, Genetic*
Transcriptional Activation

Substances

Chromatin
Histones
Lysine