Early-life microbiota as a baby metabolic guardian

Max Nieuwdorp; Melany Rios-Morales

doi:10.1016/j.cmet.2023.11.008

Early-life microbiota as a baby metabolic guardian

Cell Metab. 2023 Dec 5;35(12):2099-2100. doi: 10.1016/j.cmet.2023.11.008.

Authors

Max Nieuwdorp¹, Melany Rios-Morales²

Affiliations

¹ Department of Internal and (Experimental) Vascular Medicine, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, the Netherlands; ACS Institute, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, the Netherlands.
² Department of Internal and (Experimental) Vascular Medicine, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, the Netherlands; ACS Institute, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, the Netherlands. Electronic address: m.riosmorales@amsterdamumc.nl.

PMID: 38056427
DOI: 10.1016/j.cmet.2023.11.008

Abstract

Early-life microbiota have a crucial role in healthy development. Antibiotics, on the other hand, can disrupt this beneficial interaction and have been linked to increased adiposity in children. Shelton and collaborators went deeper into the mechanism by which microbiota protect against lipid metabolic dysfunction and diet-induced obesity. The results highlight the long-term metabolic risk of early antibiotic exposure.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Adiposity
Anti-Bacterial Agents / pharmacology
Child
Gastrointestinal Microbiome*
Humans
Infant
Microbiota*
Obesity / metabolism

Substances

Anti-Bacterial Agents