Case report: Prosthetic aortic valve endocarditis due to Staphylococcus epidermidis with acquired resistance in the walK gene

Diagn Microbiol Infect Dis. 2024 Feb;108(2):116132. doi: 10.1016/j.diagmicrobio.2023.116132. Epub 2023 Nov 11.

Abstract

We report the case of a patient with infective endocarditis on a prosthetic aortic valve due to Staphylococcus epidermidis, not a candidate for prosthetic replacement surgery. After three months of supressive treatment with dalbavancin, fever reappears, with growth of S. epidermidis. Susceptibility testing showed new-onset resistance to dalbavancin, with a mutation in walK gene.

Keywords: Dalbavancin; Resistance; Supressive treatment; walK gene.

Publication types

  • Case Reports

MeSH terms

  • Aortic Valve / surgery
  • Endocarditis*
  • Endocarditis, Bacterial* / diagnosis
  • Endocarditis, Bacterial* / drug therapy
  • Endocarditis, Bacterial* / surgery
  • Heart Valve Prosthesis* / adverse effects
  • Humans
  • Staphylococcal Infections* / diagnosis
  • Staphylococcal Infections* / drug therapy
  • Staphylococcus epidermidis / genetics