Case report: Dopamine Dysregulation Syndrome, mania, and compulsive buying in a patient with Parkinson's disease

Carlos Silva; Marta Rebelo; Inês Chendo

doi:10.3389/fneur.2023.1290653

Case report: Dopamine Dysregulation Syndrome, mania, and compulsive buying in a patient with Parkinson's disease

Front Neurol. 2023 Nov 20:14:1290653. doi: 10.3389/fneur.2023.1290653. eCollection 2023.

Authors

Carlos Silva^{1

2}, Marta Rebelo¹, Inês Chendo^{1

2

3}

Affiliations

¹ Psychiatry Department, Department of Neurosciences, Hospital de Santa Maria, Lisbon, Portugal.
² Clínica Universitária de Psiquiatria e Psicologia Médica, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal.
³ Laboratory of Clinical Pharmacology and Therapeutics, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal.

Abstract

Neuropsychiatric symptoms and syndromes are among the most common non-motor symptoms of Parkinson's Disease but they are frequently unrecognized and untreated. Dopamine Dysregulation Syndrome is an uncommon complication of the treatment of Parkinson's disease, characterized by an addictive use of dopamine far more than the dosage required for treatment of objective motor impairment, leading to severe dyskinesia, euphoria, aggressivity, or psychosis. We present a paradigmatic case of Dopamine Dysregulation Syndrome, Mania, and Compulsive Buying in a 55-year-old male with Parkinson's Disease. We also reviewed the risk factors and the therapeutic management of Dopamine Dysregulation Syndrome in Parkinson's Disease.

Keywords: Parkinson's disease; compulsive buying; dopaminergic Dysregulation Syndrome; impulsive-compulsive behaviors; mania.

Publication types

Case Reports

Grants and funding

The author(s) declare that no financial support was received for the research, authorship, and/or publication of this article.