Exploring LIPIDs for their potential to improves bioavailability of lipophilic drugs candidates: A review

Preeti; Sharda Sambhakar; Renu Saharan; Sonia Narwal; Rohit Malik; Vinod Gahlot; Asaad Khalid; Asim Najmi; Khalid Zoghebi; Maryam A Halawi; Mohammed Albratty; Syam Mohan

doi:10.1016/j.jsps.2023.101870

Exploring LIPIDs for their potential to improves bioavailability of lipophilic drugs candidates: A review

Saudi Pharm J. 2023 Dec;31(12):101870. doi: 10.1016/j.jsps.2023.101870. Epub 2023 Nov 10.

Authors

Preeti^{1

2}, Sharda Sambhakar¹, Renu Saharan³, Sonia Narwal⁴, Rohit Malik², Vinod Gahlot⁵, Asaad Khalid^{6

7}, Asim Najmi⁸, Khalid Zoghebi⁸, Maryam A Halawi⁹, Mohammed Albratty⁸, Syam Mohan^{6

10

11}

Affiliations

¹ Banasthali Vidyapith, Vanasthali Road, Aliyabad, Rajasthan 304022, India.
² Gurugram Global College of Pharmacy, Haily Mandi Rd, Farukh Nagar, Haryana 122506, India.
³ Maharishi Markandeswar Deemed to be University, Mullana, Ambala, Haryana 133203, India.
⁴ Panipat Institute of Engineering & Technology, Department of Pharmacy, GT Road, Samalkha, Panipat 132102, Haryana, India.
⁵ HIMT College of Pharmacy, Knowledge Park - 1, Greater Noida, District - Gautam Buddh Nagar, UP 201310, India.
⁶ Substance Abuse and Toxicology Research Centre, Jazan University, Jazan 45142, Saudi Arabia.
⁷ Medicinal and Aromatic Plants Research Institute, National Center for Research, P.O. Box: 2424, Khartoum 11111, Sudan.
⁸ Department of Pharmaceutical Chemistry and Pharmacognosy, College of Pharmacy, Jazan University, P.O. Box 114, Jazan, Saudi Arabia.
⁹ Department of Cinical Pharmacy, College of Pharmacy, Jazan University, P.O. Box 114, Jazan, Saudi Arabia.
¹⁰ School of Health Sciences, University of Petroleum and Energy Studies, Dehradun, Uttarakhand, India.
¹¹ Center for Global health Research, Saveetha Medical College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, India.

Abstract

This review aims to provide a thorough examination of the benefits, challenges, and advancements in utilizing lipids for more effective drug delivery, ultimately contributing to the development of innovative approaches in pharmaceutical science. Lipophilic drugs, characterized by low aqueous solubility, present a formidable challenge in achieving effective delivery and absorption within the human body. To address this issue, one promising approach involves harnessing the potential of lipids. Lipids, in their diverse forms, serve as carriers, leveraging their unique capacity to enhance solubility, stability, and absorption of these challenging drugs. By facilitating improved intestinal solubility and selective lymphatic absorption of porously permeable drugs, lipids offer an array of possibilities for drug delivery. This versatile characteristic not only bolsters the pharmacological efficacy of drugs with low bioavailability but also contributes to enhanced therapeutic performance, ultimately reducing the required dose size and associated costs. This comprehensive review delves into the strategic formulation approaches that employ lipids as carriers to ameliorate drug solubility and bioavailability. Emphasis is placed on the critical considerations of lipid type, composition, and processing techniques when designing lipid-based formulations. This review meticulously examines the multifaceted challenges that come hand in hand with lipid-based formulations for lipophilic drugs, offering an insightful perspective on future trends. Regulatory considerations and the broad spectrum of potential applications are also thoughtfully discussed. In summary, this review presents a valuable repository of insights into the effective utilization of lipids as carriers, all aimed at elevating the bioavailability of lipophilic drugs.

Keywords: Bioavailability; Drug absorption; Formulation approaches; Lipid-based micelles; Lipid-based nanoparticles; Lipids; Lipophilic drugs; Liposomes; Self-emulsifying drug delivery systems; Solubility; Stability.

Publication types

Review