Behavioral Variant Frontotemporal Dementia With the Dominantly Affected Caudate Nucleus in 18 F-FP-CIT PET/CT

Clin Nucl Med. 2024 Feb 1;49(2):154-156. doi: 10.1097/RLU.0000000000004998. Epub 2023 Dec 4.

Abstract

Frontotemporal dementia is a clinical syndrome that is characterized by a progressive deterioration in behavior, personality, and/or language, with relative preservation of memory, and its phenotype and molecular basis are heterogeneous. We present a case of a 62-year-old female patient who underwent 18 F-FDG PET/CT and 18 F-FP-CIT PET/CT for differential diagnosis of psychiatric disease and types of dementia. 18 F-FDG PET/CT image showed a compatible finding for frontotemporal dementia, and 18 F-FP-CIT PET/CT image showed dominantly decreased dopamine transporter activity in the bilateral caudate nucleus.

Publication types

  • Case Reports

MeSH terms

  • Caudate Nucleus / diagnostic imaging
  • Caudate Nucleus / metabolism
  • Dopamine Plasma Membrane Transport Proteins / metabolism
  • Female
  • Fluorodeoxyglucose F18
  • Frontotemporal Dementia* / diagnostic imaging
  • Humans
  • Middle Aged
  • Positron Emission Tomography Computed Tomography*
  • Tropanes

Substances

  • 2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropane
  • Fluorodeoxyglucose F18
  • Tropanes
  • Dopamine Plasma Membrane Transport Proteins