Non-coding RNAs modulate pyroptosis in myocardial ischemia-reperfusion injury: A comprehensive review

Yi Sun; Shujuan Chu; Rong Wang; Rui Xia; Meng Sun; Zhixiong Gao; Zhengyuan Xia; Yan Zhang; Siwei Dong; Tingting Wang

doi:10.1016/j.ijbiomac.2023.128558

Non-coding RNAs modulate pyroptosis in myocardial ischemia-reperfusion injury: A comprehensive review

Int J Biol Macromol. 2024 Feb;257(Pt 1):128558. doi: 10.1016/j.ijbiomac.2023.128558. Epub 2023 Dec 2.

Authors

Yi Sun¹, Shujuan Chu¹, Rong Wang¹, Rui Xia¹, Meng Sun¹, Zhixiong Gao¹, Zhengyuan Xia², Yan Zhang¹, Siwei Dong³, Tingting Wang⁴

Affiliations

¹ Department of Anesthesiology, Union Hosptial, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Institute of Anesthesia and Critical Care Medicine, Union Hosptial, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Key Laboratory of Anesthesiology and Resuscitation (Huazhong University of Science and Technology), Ministry of Education, China.
² Department of Anesthesiology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, China.
³ Department of Anesthesiology, Union Hosptial, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Institute of Anesthesia and Critical Care Medicine, Union Hosptial, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Key Laboratory of Anesthesiology and Resuscitation (Huazhong University of Science and Technology), Ministry of Education, China. Electronic address: 2013xh0970@hust.edu.cn.
⁴ Department of Anesthesiology, Union Hosptial, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Institute of Anesthesia and Critical Care Medicine, Union Hosptial, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Key Laboratory of Anesthesiology and Resuscitation (Huazhong University of Science and Technology), Ministry of Education, China. Electronic address: 2012xh0702@hust.edu.cn.

PMID: 38048927
DOI: 10.1016/j.ijbiomac.2023.128558

Abstract

Reperfusion therapy is the most effective treatment for acute myocardial infarction. However, reperfusion itself can also cause cardiomyocytes damage. Pyroptosis has been shown to be an important mode of myocardial cell death during ischemia-reperfusion. Non-coding RNAs (ncRNAs) play critical roles in regulating pyroptosis. The regulation of pyroptosis by microRNAs, long ncRNAs, and circular RNAs may represent a new mechanism of myocardial ischemia-reperfusion injury. This review summarizes the currently known regulatory roles of ncRNAs in myocardial ischemia-reperfusion injury and interactions between ncRNAs. Potential therapeutic strategies using ncRNA modulation are also discussed.

Keywords: Myocardial ischemia-reperfusion injury; Non-coding RNAs; Pyroptosis.

Publication types

Review

MeSH terms

Humans
MicroRNAs* / genetics
MicroRNAs* / metabolism
Myocardial Infarction* / genetics
Myocardial Reperfusion Injury* / genetics
Myocardial Reperfusion Injury* / metabolism
Pyroptosis / genetics
RNA, Untranslated / genetics

Substances

MicroRNAs
RNA, Untranslated