A Fluid-Solid-Growth Solver for Cardiovascular Modeling

Comput Methods Appl Mech Eng. 2023 Dec 15;417(Pt B):116312. doi: 10.1016/j.cma.2023.116312. Epub 2023 Aug 9.

Abstract

We implement full, three-dimensional constrained mixture theory for vascular growth and remodeling into a finite element fluid-structure interaction (FSI) solver. The resulting "fluid-solid-growth" (FSG) solver allows long term, patient-specific predictions of changing hemodynamics, vessel wall morphology, tissue composition, and material properties. This extension from short term (FSI) to long term (FSG) simulations increases clinical relevance by enabling mechanobioloigcally-dependent studies of disease progression in complex domains.