LINC00319: Unraveling the spectrum from gene regulation to clinical applications in cancer progression

Xinming Su; Lingtao Yan; Jiahua Si; Zehua Wang; Chenhao Liang; Kehao Peng; Jinze Shen; Shiwei Duan

doi:10.1016/j.gene.2023.148044

LINC00319: Unraveling the spectrum from gene regulation to clinical applications in cancer progression

Gene. 2024 Feb 20:896:148044. doi: 10.1016/j.gene.2023.148044. Epub 2023 Nov 30.

Authors

Xinming Su¹, Lingtao Yan², Jiahua Si¹, Zehua Wang¹, Chenhao Liang¹, Kehao Peng³, Jinze Shen¹, Shiwei Duan⁴

Affiliations

¹ Key Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province, School of Medicine, Hangzhou City University, Hangzhou, Zhejiang, China; Department of Clinical Medicine, Hangzhou City University, Hangzhou, Zhejiang, China.
² Medical Genetics Center, Department of Medicine, Ningbo University, Ningbo, Zhejiang, China.
³ The Second School of Medicine, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
⁴ Key Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province, School of Medicine, Hangzhou City University, Hangzhou, Zhejiang, China; Department of Clinical Medicine, Hangzhou City University, Hangzhou, Zhejiang, China. Electronic address: duansw@hzcu.edu.cn.

PMID: 38042213
DOI: 10.1016/j.gene.2023.148044

Abstract

LncRNAs are RNA transcripts that exceed 200 nucleotides in length and do not encode proteins. LINC00319 is a type of lncRNA that is highly expressed in various cancers and is regulated by CCL18 and MYC. High levels of LINC00319 are associated with poorer prognosis and more malignant clinical features in cancer patients. LINC00319 can regulate the expression of downstream genes, including 2 protein-coding genes and 11 miRNAs. It participates in controlling three signaling pathways and various cellular behaviors. LINC00319 and its downstream genes are potential targets for cancer therapy and are associated with common cancer treatments. This article reviews the abnormal expression of LINC00319 in human cancers and related molecular mechanisms, providing clues for further diagnosis and treatment.

Keywords: LINC00319; Prognostic value; Regulation mechanism; lncRNA; miRNA.

Publication types

Review

MeSH terms

Cell Line, Tumor
Cell Proliferation / genetics
Gene Expression Regulation, Neoplastic
Humans
MicroRNAs* / genetics
Neoplasms* / genetics
Neoplasms* / therapy
RNA, Long Noncoding* / genetics
RNA, Long Noncoding* / metabolism
Up-Regulation

Substances

MicroRNAs
RNA, Long Noncoding