An innovative viewpoint on the existing and prospectiveness of SR-B1

Curr Probl Cardiol. 2024 Feb;49(2):102226. doi: 10.1016/j.cpcardiol.2023.102226. Epub 2023 Nov 30.

Abstract

Scavenger Receptor Class B Type 1 (SR-B1), a receptor protein expressed on the cell membrane, plays a crucial role in the metabolism and transport of cholesterol and other lipids, contributing significantly to the homeostasis of lipid levels within the body. Bibliometric analysis involves the application of mathematical and statistical methods to quantitatively analyze different types of documents. It involves the analysis of structural and temporal trends in scholarly articles, coupled with the identification of subject emphasis and variations. Through a bibliometric analysis, this study examines the historical background, current research trends, and future directions in the exploration of SR-B1. By offering insights into the research status and development of SR-B1, this paper aims to assist researchers in identifying novel pathways and areas of investigation in this field of study. Following the screening process, it can be concluded that research on SR-B1 has consistently remained a topic of significant interest over the past 17 years. Interestingly, SR-B1 has recently garnered attention in areas beyond its traditional research focus, including the field of cancer. The primary objective of this review is to provide a concise and accessible overview of the development process of SR-B1 that can help readers who are not well-versed in SR-B1 research quickly grasp its key aspects. Furthermore, this review aims to offer insights and suggestions to researchers regarding potential future research directions and areas of emphasis relating to SR-B1.

Keywords: Atherosclerosis; Cardiovascular disease; Cholesterol; SR-B1.

Publication types

  • Review

MeSH terms

  • Cholesterol* / metabolism
  • Humans
  • Scavenger Receptors, Class B / metabolism

Substances

  • Cholesterol
  • Scavenger Receptors, Class B
  • SCARB1 protein, human