Individual resting-state network functional connectivity predicts treatment improvement of repetitive transcranial magnetic stimulation in major depressive disorder: A pilot study

Zhiliang Long; Lian Du; Marco Marino

doi:10.1016/j.psychres.2023.115616

Individual resting-state network functional connectivity predicts treatment improvement of repetitive transcranial magnetic stimulation in major depressive disorder: A pilot study

Psychiatry Res. 2024 Jan:331:115616. doi: 10.1016/j.psychres.2023.115616. Epub 2023 Nov 20.

Authors

Zhiliang Long¹, Lian Du², Marco Marino³

Affiliations

¹ Sleep and NeuroImaging Center, Faculty of Psychology, Southwest University, Chongqing, PR China. Electronic address: longzhiliangswu@gmail.com.
² Department of Psychiatry, The First Affliated Hospital of Chongqing Medical University, Chongqing, PR China.
³ KU Leuven, Movement Control & Neuroplasticity Research Group, Leuven, Belgium; Department of General Psychology, University of Padua, Italy.

PMID: 38039648
DOI: 10.1016/j.psychres.2023.115616

Abstract

The current pilot study aimed to exploratively investigate whether individual functional connectivity (FC) of the rTMS stimulation site with resting-state networks could predict the individual efficacy of rTMS treatment. We found that rTMS induced an increase of the FC between the stimulation site and the limbic network (LN) in healthy participants, and that this individualized FC was negatively correlated with the rTMS treatment improvement in MDD patients. Moreover, the LN successfully guided the personalized rTMS therapy. These findings highlighted the crucial role of the LN in understanding the mechanisms underlying rTMS treatment improvement, and the personalized therapy in MDD patients.

Keywords: Major depressive disorder; Repetitive transcranial magnetic stimulation; Resting-state network.

MeSH terms

Depressive Disorder, Major* / diagnostic imaging
Depressive Disorder, Major* / therapy
Humans
Magnetic Resonance Imaging
Pilot Projects
Prefrontal Cortex
Transcranial Magnetic Stimulation*
Treatment Outcome