Genome sequence of a measles virus strain with a novel loss of stop codon mutation in the phosphoprotein gene

Vanessa Zubach; Helene Schulz; Kihun Kim; Darian Hole; Alberto Severini; Joanne Hiebert

doi:10.1128/MRA.00833-23

Genome sequence of a measles virus strain with a novel loss of stop codon mutation in the phosphoprotein gene

Microbiol Resour Announc. 2024 Jan 17;13(1):e0083323. doi: 10.1128/MRA.00833-23. Epub 2023 Dec 1.

Authors

Vanessa Zubach¹, Helene Schulz¹, Kihun Kim², Darian Hole³, Alberto Severini^{1

4}, Joanne Hiebert¹

Affiliations

¹ Viral Exanthemata and STD Section, National Microbiology Laboratory, Public Health Agency of Canada, JC Wilt infectious Diseases Research Center , Winnipeg, Manitoba, Canada.
² Department of Microbiology, University of Manitoba , Winnipeg, Manitoba, Canada.
³ Computational and Operational Genomics Section, National Microbiology Laboratory, Public Health Agency of Canada , Winnipeg, Manitoba, Canada.
⁴ Department of Medical Microbiology and Infectious Diseases, Faculty of Health Sciences, University of Manitoba , Winnipeg, Manitoba, Canada.

Abstract

Measles virus genotype B3 coding-complete genome sequence from a 2019 case showed a novel mutation in the phosphoprotein (P) gene that abrogates the established stop codon. A downstream stop codon has been identified, resulting in a putative P that would be 19 amino acids longer than wild type.

Keywords: NGS; measles virus; novel phosphoprotein.