A new sulphur-containing metabolite from a mangrove endophytic fungus Aspergillus sp. GXNU-MA

Furong Wu; Wenxiu Zhang; Xianglong Bo; Qin Feng; Meijing Tan; Shichao Ju; Zishuo Song; Jun Li; Xishan Huang

doi:10.1080/14786419.2023.2288685

A new sulphur-containing metabolite from a mangrove endophytic fungus Aspergillus sp. GXNU-MA

Nat Prod Res. 2023 Dec 1:1-6. doi: 10.1080/14786419.2023.2288685. Online ahead of print.

Authors

Furong Wu¹, Wenxiu Zhang², Xianglong Bo¹, Qin Feng¹, Meijing Tan¹, Shichao Ju¹, Zishuo Song¹, Jun Li¹, Xishan Huang¹

Affiliations

¹ State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, College of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin, P. R. China.
² School of Chemistry and Bioengineering, Hechi University, Yizhou, China.

PMID: 38037915
DOI: 10.1080/14786419.2023.2288685

Abstract

A new sulphur-containing metabolite, asperiguxidione A (1), was isolated from a mangrove endophytic fungus Aspergillus sp. GXNU-MA, and four known alkaloids 2-5, were isolated together from this strain. Their structures were determined by the com-bination of 1D and 2D NMR spectroscopy, HR-ESI-MS, and ECD analysis. Compounds 1 and 2 exhibited mediate activity against Staphylococcus aureus and Enterobacter aerogenes with equal MIC values of 12.5 μg/mL. Compound 3 reduced NO production in LPS-stimulated cells with an IC₅₀ value of 13.329 ± 0.53 μg/mL in the anti-inflammatory assay.

Keywords: Aspergillus sp; anti-inflammatory; antibacterial; asperiguxidione A; endophytic fungus.