Dentin hypersensitivity treatment is not always successful owing to the exfoliation of the blocking layer. Therefore, efficiently delivering a desensitization agent into the dental tubule is critical. Nanomotors are widely used as in vivo drug delivery systems owing to their strong power and good biocompatibility. Herein, we report a kind of self-propelled bioglass Janus nanomotor with a Pt motion unit (nBGs@Pt) for application in dentin hypersensitivity that was prepared via a simple sol-gel method and magnetron sputtering method, with an average size of 290 nm. The Pt layer as the power unit provided the dynamics to deliver the bioglass (desensitization agent). Using hydrogen peroxide as a fuel, the nBGs@Pt could automatically move in different media. In addition, the nBGs@Pt with a mesoporous structure demonstrated good hydroxyapatite formation performance. An in vitro dentin pressure model was used to verify the blocking ability of the nBGs@Pt in dentin tubules. The dynamics of the nBGs@Pt was sufficient to resist the outflow of dentin fluid and movement into the dentin tubules, with a blocking rate of 58.05%. After remineralization, the blocking rate could reach 96.07% and the formation of hydroxyapatite of up to 10 μm or more occurred. It is expected that this study will provide a simple and feasible new strategy for the painless treatment of dentin sensitivity.