Omicron Infections in Vaccinated Pediatric Solid Organ Transplant Recipients

John McAteer; Divya D Kalluri; Rivka R Abedon; Caroline X Qin; Scott R Auerbach; Olga Charnaya; Lara A Danziger-Isakov; Noelle H Ebel; Amy G Feldman; Evelyn K Hsu; Saeed Mohammad; Emily R Perito; Ashley M Thomas; Teresa P Y Chiang; Jacqueline M Garonzik-Wang; Dorry L Segev; William A Werbel; Douglas B Mogul

doi:10.1093/jpids/piad108

Omicron Infections in Vaccinated Pediatric Solid Organ Transplant Recipients

J Pediatric Infect Dis Soc. 2024 Feb 26;13(2):152-154. doi: 10.1093/jpids/piad108.

Authors

John McAteer^{1

2}, Divya D Kalluri³, Rivka R Abedon³, Caroline X Qin^{2

3}, Scott R Auerbach⁴, Olga Charnaya², Lara A Danziger-Isakov⁵, Noelle H Ebel⁶, Amy G Feldman⁷, Evelyn K Hsu⁸, Saeed Mohammad⁹, Emily R Perito¹⁰, Ashley M Thomas¹¹, Teresa P Y Chiang³, Jacqueline M Garonzik-Wang¹², Dorry L Segev¹³, William A Werbel³, Douglas B Mogul¹¹

Affiliations

¹ Division of Infectious Diseases, Department of Pediatrics, Johns Hopkins Children's Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
² Division of Nephrology, Department of Pediatrics, Johns Hopkins Children's Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
³ Department of Surgery, The Johns Hopkins Hospital, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
⁴ Division of Cardiology, Department of Pediatrics, Children's Hospital Colorado, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
⁵ Division of Infectious Diseases, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio, USA.
⁶ Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Lucile Packard Children's Hospital Stanford, Stanford University School of Medicine, Palo Alto, California, USA.
⁷ Section of Gastroenterology, Hepatology and Nutrition, Digestive Health Institute, Children's Hospital Colorado, University of Colorado Denver School of Medicine, Aurora, Colorado, USA.
⁸ Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Seattle Children's Hospital, University of Washington School of Medicine, Seattle, Washington, USA.
⁹ Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Vanderbilt University Medical Center, Vanderbilt University, Nashville, Tennessee, USA.
¹⁰ Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, University of California San Francisco Benioff Children's Hospital, University of California San Francisco, San Francisco, California, USA.
¹¹ Section of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Johns Hopkins Children's Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
¹² Department of Surgery, NYU Grossman School of Medicine, New York City, New York, USA.
¹³ Division of Transplant Surgery, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Milwaukee, Wisconsin, USA.

PMID: 38035755
PMCID: PMC10896257 (available on 2024-11-30)
DOI: 10.1093/jpids/piad108

Abstract

SARS-CoV-2 infection during the Omicron period was frequent amongst a cohort of vaccinated pediatric solid organ transplant recipients (pSOTRs) despite robust anti-receptor-binding domain (anti-RBD) antibody response, suggesting poor neutralizing capacity against Omicron subvariants. Breakthrough infections among pSOTRs were overall limited in severity.

Keywords: COVID-19; Omicron variant; breakthrough; mRNA vaccination; pediatrics; solid organ transplant.

© The Author(s) 2023. Published by Oxford University Press on behalf of The Journal of the Pediatric Infectious Diseases Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

MeSH terms

COVID-19* / prevention & control
Child
Humans
Organ Transplantation* / adverse effects
Transplant Recipients
Vaccination

Grants and funding

K08 DK134762/DK/NIDDK NIH HHS/United States