Tumor diagnosis using carbon-based quantum dots: Detection based on the hallmarks of cancer

Hang Wang; Siwei Yang; Liangfeng Chen; Yongqiang Li; Peng He; Gang Wang; Hui Dong; Peixiang Ma; Guqiao Ding

doi:10.1016/j.bioactmat.2023.10.004

Tumor diagnosis using carbon-based quantum dots: Detection based on the hallmarks of cancer

Bioact Mater. 2023 Nov 15:33:174-222. doi: 10.1016/j.bioactmat.2023.10.004. eCollection 2024 Mar.

Authors

Hang Wang^{1

2

3}, Siwei Yang^{1

3}, Liangfeng Chen^{1

3}, Yongqiang Li^{1

3}, Peng He^{1

3}, Gang Wang⁴, Hui Dong^{1

2

3}, Peixiang Ma⁵, Guqiao Ding^{1

3}

Affiliations

¹ National Key Laboratory of Materials for Integrated Circuit, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, Shanghai, 200050, PR China.
² CAS Center for Excellence in Superconducting Electronics (CENSE), Chinese Academy of Sciences, Shanghai, 200050, PR China.
³ Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences (UCAS), Beijing, 100049, PR China.
⁴ Department of Microelectronic Science and Engineering, School of Physical Science and Technology, Ningbo University, Ningbo, 315211, PR China.
⁵ Shanghai Key Laboratory of Orthopedic Implants, Department of Orthopedic Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, PR China.

Abstract

Carbon-based quantum dots (CQDs) have been shown to have promising application value in tumor diagnosis. Their use, however, is severely hindered by the complicated nature of the nanostructures in the CQDs. Furthermore, it seems impossible to formulate the mechanisms involved using the inadequate theoretical frameworks that are currently available for CQDs. In this review, we re-consider the structure-property relationships of CQDs and summarize the current state of development of CQDs-based tumor diagnosis based on biological theories that are fully developed. The advantages and deficiencies of recent research on CQDs-based tumor diagnosis are thus explained in terms of the manifestation of nine essential changes in cell physiology. This review makes significant progress in addressing related problems encountered with other nanomaterials.

Keywords: Carbon-based quantum dots; Cell physiology; Hallmarks of cancer; Structure design; Tumor diagnosis.

Publication types

Review