Primary CNS ALK-negative anaplastic large cell lymphoma: A case report and review of the literature

Amy L Brady; Christine E Fuller; Sohil Patel; Walter Hall; Katalin Banki; Krishna B Ghimire

doi:10.1016/j.radcr.2023.09.095

Primary CNS ALK-negative anaplastic large cell lymphoma: A case report and review of the literature

Radiol Case Rep. 2023 Nov 10;19(1):393-399. doi: 10.1016/j.radcr.2023.09.095. eCollection 2024 Jan.

Authors

Amy L Brady¹, Christine E Fuller¹, Sohil Patel², Walter Hall¹, Katalin Banki¹, Krishna B Ghimire³

Affiliations

¹ Department of Pathology, SUNY Upstate Medical University, Syracuse, NY, USA.
² Department of Neuroradiology, University of Virginia, Charlottesville, VA, USA.
³ Department of Medicine, Hematology and Medical Oncology, SUNY Upstate Medical University, Syracuse, NY, USA.

Abstract

Primary central nervous system (CNS) ALK-negative anaplastic large cell lymphoma (ALCL) is a rare and enigmatic disease, with limited data available in the literature. This case report adds to the existing body of knowledge by describing a unique case of a 68-year-old, immunocompetent male who presented with a single ring-enhancing lesion, which upon further analysis proved to be an ALK-negative ALCL that was primary to the CNS. A comprehensive review of the existing literature is provided, highlighting the genetic characteristics and diverse neuroimaging findings of this disease entity. This report adds valuable information to the understanding of this rare disorder, and highlights the need for further research in the field of primary CNS ALK-negative ALCL.

Keywords: ALK-negative; Anaplastic large cell lymphoma; IRF4/DUSP22; Neuroradiology findings; Primary central nervous system lymphomas.

Publication types

Case Reports