Dynamic prediction of survival via Landmark method using the asthma prevention trial in young children

PLoS One. 2023 Nov 30;18(11):e0293796. doi: 10.1371/journal.pone.0293796. eCollection 2023.

Abstract

This paper focuses on the applications of Landmark method for obtaining dynamic predictions of survival by using Landmark approach to the data of asthma prevention trial in young children. This work focuses on the different ways to model recurrent events by considering various time scales according to how subjects in the dataset experienced multiple events. Landmark models can be used to dynamically estimate the effect of treatments effects whilst also taken into consideration the history of previous asthma attacks. Our analysis show that the treatment effect should be modelled with a time varying effect and the effect of the previous attack reduces with the passage of time.

MeSH terms

  • Asthma* / prevention & control
  • Child, Preschool
  • Clinical Trials as Topic
  • Humans

Grants and funding

The authors received no specific funding for this work.