Optogenetic and chemogenetic approaches reveal differences in neuronal circuits that mediate initiation and maintenance of social interaction

Karolina Rojek-Sito; Ksenia Meyza; Karolina Ziegart-Sadowska; Kinga Nazaruk; Alicja Puścian; Adam Hamed; Michał Kiełbiński; Wojciech Solecki; Ewelina Knapska

doi:10.1371/journal.pbio.3002343

Optogenetic and chemogenetic approaches reveal differences in neuronal circuits that mediate initiation and maintenance of social interaction

PLoS Biol. 2023 Nov 29;21(11):e3002343. doi: 10.1371/journal.pbio.3002343. eCollection 2023 Nov.

Authors

Karolina Rojek-Sito¹, Ksenia Meyza¹, Karolina Ziegart-Sadowska¹, Kinga Nazaruk¹, Alicja Puścian¹, Adam Hamed², Michał Kiełbiński³, Wojciech Solecki³, Ewelina Knapska¹

Affiliations

¹ Laboratory of Emotions Neurobiology, BRAINCITY-Centre of Excellence for Neural Plasticity and Brain Disorders, Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw, Poland.
² Laboratory of Spatial Memory, Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw, Poland.
³ Department of Neurobiology and Neuropsychology, Institute of Applied Psychology, Jagiellonian University, Krakow, Poland.

Abstract

For social interaction to be successful, two conditions must be met: the motivation to initiate it and the ability to maintain it. This study uses both optogenetic and chemogenetic approaches to reveal the specific neural pathways that selectively influence those two social interaction components.

Copyright: © 2023 Rojek-Sito et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

MeSH terms

Cognition
Motivation
Neural Pathways / physiology
Neurons / physiology
Optogenetics*
Social Interaction*

Grants and funding

This work was supported by the European Research Council Starting Grant (H 415148) to EK (supporting the work of KRS, KM, KZS, KN, AH, and EK) and the BRAINCITY - Centre of Excellence for Neural Plasticity and Brain Disorders’ project of the Foundation for Polish Science to EK (supporting the work of KRS, AP, and EK). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.