Role of Lymphangiogenesis in Cardiac Repair and Regeneration

Zhongyun Xu; Qing Lu; Liming Chen; Chengchao Ruan; Yingnan Bai; Yunzeng Zou; Junbo Ge

doi:10.14797/mdcvj.1286

Role of Lymphangiogenesis in Cardiac Repair and Regeneration

Methodist Debakey Cardiovasc J. 2023 Nov 16;19(5):37-46. doi: 10.14797/mdcvj.1286. eCollection 2023.

Authors

Zhongyun Xu^#¹, Qing Lu^#¹, Liming Chen², Chengchao Ruan³, Yingnan Bai⁴, Yunzeng Zou⁴, Junbo Ge^{4

5

6

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Affiliations

¹ Shanghai East Hospital Tongji University, Shanghai, China.
² Fudan University, Shanghai, China.
³ School of Basic Medical Sciences, Fudan University, Shanghai, China.
⁴ Zhongshan Hospital, Fudan University, Shanghai, China.
⁵ National Clinical Research Center for Interventional Medicine, Shanghai, China.
⁶ National Health Commission, Shanghai, China.
⁷ Chinese Academy of Medical Sciences, Shanghai, China.

^# Contributed equally.

Abstract

This article highlights the importance of the structure and function of cardiac lymphatics in cardiovascular diseases and the therapeutic potential of cardiac lymphangiogenesis. Specifically, we explore the innate lymphangiogenic response to damaged cardiac tissue or cardiac injury, derive key findings from regenerative models demonstrating how robust lymphangiogenic responses can be supported to improve cardiac function, and introduce an approach to imaging the structure and function of cardiac lymphatics.

Keywords: cardiac lymphangiogenesis; cardiac lymphatic structure; lymphatic visualization.

Publication types

Review

MeSH terms

Cardiovascular Diseases*
Heart
Humans
Lymphangiogenesis / physiology
Lymphatic Vessels* / physiology
Regeneration

Grants and funding

This study was supported by the National Natural Science Foundation of China (81900434), and the Fudan University (IDF152064/016).