Association between triglyceride glucose index and H-type hypertension in postmenopausal women

Zihao Ding; Shihong Du; Yi Yang; Tong Yu; Xiuqin Hong

doi:10.3389/fcvm.2023.1224296

Association between triglyceride glucose index and H-type hypertension in postmenopausal women

Front Cardiovasc Med. 2023 Nov 1:10:1224296. doi: 10.3389/fcvm.2023.1224296. eCollection 2023.

Authors

Zihao Ding^{1

2

3}, Shihong Du^{1

2

3}, Yi Yang^{1

2}, Tong Yu^{1

2

3}, Xiuqin Hong^{1

2

4}

Affiliations

¹ Clinical Epidemiology Research Office, The First Affiliated Hospital of Hunan Normal University, Changsha, China.
² Key Laboratory of Molecular Epidemiology, Hunan Normal University, Changsha, China.
³ Department of Epidemiology and Statistics, College of Medicine, Hunan Normal University, Changsha, China.
⁴ Research Department, The First Affiliated Hospital of Hunan Norma University, Changsha, China.

Abstract

Background: Recent studies have reported better predictive performance of triglyceride glucose (TyG) index for cardiovascular events in women, however, whether this association persists in postmenopausal women is inconclusive. We investigated the association between TyG index and H-type hypertension (HHT) in postmenopausal women.

Methods: 1,301 eligible women with hypertension were included in this cross-sectional study. Concomitant homocysteine levels >10 μmol/L were defined as H-type hypertension. The TyG index was calculated as ln [triglycerides (mg/dl) × fasting glucose (mg/dl)/2]. Multivariable logistic regression models and restricted cubic spline models were used to assess the association between TyG index and H-type hypertension in postmenopausal women, and subgroup analyses were performed for potential confounders.

Results: Of the 1,301 hypertensive patients, 634 (48.7%) participants had H-type hypertension. In each adjusted model, TyG index was significantly associated with the risk of H-type hypertension. each 1-unit increase in TyG index was associated with an increased risk of H-type hypertension in all participants (OR = 1.6; 95% CI, 1.3-2.0; P < 0.001), and there was a linear relationship between TyG index and H-type hypertension (P for linear trend < 0.001).

Conclusion: TyG index is positively associated with H-type hypertension in postmenopausal women, suggesting that TyG index may be a promising marker for H-type hypertension. By controlling lipid levels and blood glucose levels, it may help prevent H-type hypertension in postmenopausal women.

Keywords: H-type hypertension; cross-sectional study; insulin resistance; postmenopausal women; triglyceride glucose index.

Grants and funding

This study was funded by the National Natural Science Foundation of China (8177120863), Hunan Provincial Science and Technology Department (2020JJ4047) and Science and Technology Bureau, Changsha (kq1801096).