Efficient conversion of carbohydrates into 5-hydroxymethylfurfural using choline chloride-based deep eutectic solvents

Dung Kim Thi Ngo; Trinh Hao Nguyen; Phat Ngoc Nguyen; Hai Truong Nguyen; Trinh Ngoc Thi Huynh; Ha Bich Phan; Phuong Hoang Tran

doi:10.1016/j.heliyon.2023.e21274

Efficient conversion of carbohydrates into 5-hydroxymethylfurfural using choline chloride-based deep eutectic solvents

Heliyon. 2023 Oct 30;9(11):e21274. doi: 10.1016/j.heliyon.2023.e21274. eCollection 2023 Nov.

Authors

Dung Kim Thi Ngo¹, Trinh Hao Nguyen^{2

3}, Phat Ngoc Nguyen^{2

3}, Hai Truong Nguyen^{2

3}, Trinh Ngoc Thi Huynh¹, Ha Bich Phan^{2

3

4}, Phuong Hoang Tran^{2

3}

Affiliations

¹ Faculty of General Sciences, Tra Vinh University, Tra Vinh City, Tra Vinh Province, Viet Nam.
² Department of Organic Chemistry, Faculty of Chemistry, University of Science, Ho Chi Minh City, Viet Nam.
³ Vietnam National University, Ho Chi Minh City, Viet Nam.
⁴ Institute of Public Health, Ho Chi Minh City, Viet Nam.

Abstract

In this study, the conversion of monosaccharides to 5-hydroxymethylfurfural (5-HMF) using different deep eutectic solvents (DESs) was investigated in various conditions. Among all the investigated DESs, [ChCl][trichloroacetic acid], based on choline chloride and trichloroacetic acid with the ratio 1:1, showed the highest catalytic activity. A maximum 5-HMF yield was 82 % for 1 h at 100 °C using [ChCl][trichloroacetic acid] as a catalyst from fructose. [ChCl][trichloroacetic acid] could be recovered and reused three times with a slight loss in activity. Our work demonstrated the low-cost and effective method for the synthesis of 5-HMF from carbohydrates.

Keywords: 5-Hydroxymethylfurfural; Choline chloride; Deep eutectic solvents; Fructose.