Association between triglyceride glucose-body mass index and heart failure in subjects with diabetes mellitus or prediabetes mellitus: a cross-sectional study

Front Endocrinol (Lausanne). 2023 Nov 3:14:1294909. doi: 10.3389/fendo.2023.1294909. eCollection 2023.

Abstract

Background: The triglyceride glucose-body mass index (TyG-BMI) is a surrogate indicator of insulin resistance. However, the association of TyG-BMI with heart failure (HF) in individuals with diabetes mellitus or prediabetes mellitus is unknown.

Methods: This study included 7,472 participants aged 20-80 years old with prediabetes or diabetes from the National Health and Nutrition Examination Survey (2007-2018). The TyG-BMI was calculated as Ln [triglyceride (mg/dL) × fasting blood glucose (mg/dL)/2] × BMI, and individuals were categorized into tertiles based on TyG-BMI levels. The relationship of TyG-BMI with HF was analyzed using multiple logistic regression models. Subgroup analyses were stratified by gender, age, hypertension, and diabetes mellitus status.

Results: This cross-sectional study had 7,472 participants (weighted n = 111,808,357), including 329 HF participants. Participants with a high TyG-BMI were prone to HF. The highest tertile group with a fully adjusted model was more likely to have HF compared to the lowest tertile group (odds ratio [OR], 2.645; 95% CI, 1.529-4.576). Restricted cubic spline analysis showed a significant dose-response relationship between TyG-BMI and HF (P < 0.001). In subgroup analyses, similar results were seen in terms of age (≥50 years old), gender, hypertension, and diabetes mellitus status.

Conclusion: A high TyG-BMI is significantly associated with HF risk in participants with diabetes mellitus or prediabetes mellitus.

Keywords: NHANES; diabetes mellitus; heart failure; insulin resistance; prediabetes mellitus; triglyceride glucose-body mass index.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Blood Glucose / analysis
  • Body Mass Index
  • Cross-Sectional Studies
  • Diabetes Mellitus, Type 2*
  • Glucose
  • Heart Failure* / epidemiology
  • Heart Failure* / etiology
  • Humans
  • Hypertension*
  • Middle Aged
  • Nutrition Surveys
  • Prediabetic State* / complications
  • Prediabetic State* / diagnosis
  • Prediabetic State* / epidemiology
  • Risk Factors
  • Triglycerides
  • Young Adult

Substances

  • Glucose
  • Triglycerides
  • Blood Glucose

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This study was supported by the Jiangsu Provincial Health Commission Project Fund (Grant number: M2020015), Jiangsu Provincial Science and Technology Department Social Development Fund (Grant number: BE2019639), Jiangsu Traditional Chinese Medicine Science and Technology Development Plan Project (Grant number: YB201988), Xuzhou Innovative plan to Promote Science Technology (Grant number: KC21192), and Xuzhou Practical Innovation Program for University Students (Grant number: SJCX23_1389).