The role of retinoic acid receptor-related orphan receptors in skeletal diseases

Yifan Zhang; Jun Ma; Xingfu Bao; Min Hu; Xiaoxi Wei

doi:10.3389/fendo.2023.1302736

The role of retinoic acid receptor-related orphan receptors in skeletal diseases

Front Endocrinol (Lausanne). 2023 Nov 8:14:1302736. doi: 10.3389/fendo.2023.1302736. eCollection 2023.

Authors

Yifan Zhang¹, Jun Ma², Xingfu Bao¹, Min Hu¹, Xiaoxi Wei¹

Affiliations

¹ Department of Orthodontics, Hospital of Stomatology Jilin University, Changchun, Jilin, China.
² Department of Oral Anatomy and Physiology, Hospital of Stomatology Jilin University, Changchun, Jilin, China.

Abstract

Bone homeostasis, depending on the balance between bone formation and bone resorption, is responsible for maintaining the proper structure and function of the skeletal system. As an important group of transcription factors, retinoic acid receptor-related orphan receptors (RORs) have been reported to play important roles in bone homeostasis by regulating the transcription of target genes in skeletal cells. On the other hand, the dysregulation of RORs often leads to various skeletal diseases such as osteoporosis, rheumatoid arthritis (RA), and osteoarthritis (OA). Herein, we summarized the roles and mechanisms of RORs in skeletal diseases, aiming to provide evidence for potential therapeutic strategies.

Keywords: RORs; bone homeostasis; osteoarthritis; osteoporosis; rheumatoid arthritis.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Homeostasis
Receptors, Retinoic Acid* / genetics
Transcription Factors*

Substances

Receptors, Retinoic Acid
Transcription Factors

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was supported by the National Natural Science Foundation of China [grant number NSFC-82001083]; the Natural Science Foundation of Jilin Province for Youths [grant number YDZJ2023ZYTS468].