Advances of nanoparticle-mediated diagnostic and theranostic strategies for atherosclerosis

Lin Lin; Lin Chen; Juan Yan; Peirong Chen; Jiahui Du; Junpeng Zhu; Xinyu Yang; Boxin Geng; Lang Li; Wen Zeng

doi:10.3389/fbioe.2023.1268428

Advances of nanoparticle-mediated diagnostic and theranostic strategies for atherosclerosis

Front Bioeng Biotechnol. 2023 Nov 9:11:1268428. doi: 10.3389/fbioe.2023.1268428. eCollection 2023.

Authors

Lin Lin^#^{1

2

3}, Lin Chen^#², Juan Yan^#^{2

3}, Peirong Chen^#², Jiahui Du^#^{2

3}, Junpeng Zhu^#^{2

3}, Xinyu Yang^{2

3}, Boxin Geng^{2

3}, Lang Li^{2

3}, Wen Zeng^{1

2

3}

Affiliations

¹ School of Medicine, Chongqing University, Chongqing, China.
² Department of Cell Biology, Third Military Medical University, Chongqing, China.
³ Jinfeng Laboratory, Chongqing, China.

^# Contributed equally.

Abstract

Atherosclerotic plaque remains the primary cause of morbidity and mortality worldwide. Accurate assessment of the degree of atherosclerotic plaque is critical for predicting the risk of atherosclerotic plaque and monitoring the results after intervention. Compared with traditional technology, the imaging technologies of nanoparticles have distinct advantages and great development prospects in the identification and characterization of vulnerable atherosclerotic plaque. Here, we systematically summarize the latest advances of targeted nanoparticle approaches in the diagnosis of atherosclerotic plaque, including multimodal imaging, fluorescence imaging, photoacoustic imaging, exosome diagnosis, and highlighted the theranostic progress as a new therapeutic strategy. Finally, we discuss the major challenges that need to be addressed for future development and clinical transformation.

Keywords: atherosclerosis diagnosis; exosome; multimodal imaging; theranostic; vulnerable plaque.

Publication types

Review

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was supported by grants from the National Key R&D Program of China (2021YFA1102100); National Defense Fund for Excellent Young Scholars (2021-JCJQ-ZQ-003); Science Fund for Distinguished Young Scholars of Chongqing (cstc2020jcyj-jqX0023); University Innovation Research Group of Chongqing(CXQT21010).