Season of delivery and risk of venous thromboembolism during hospitalization among pregnant women

Qian Li; Hongfei Wang; Huafang Wang; Jun Deng; Zhipeng Cheng; Wenyi Lin; Ruiqi Zhu; Shi Chen; Jinrong Guo; Huarong Li; Yong Chen; Xiaowei Yuan; Shulan Dai; Yan Tian; Yanyan Xu; Ping Wu; Fan Zhang; Xiaojiang Wang; Liang V Tang; Yu Hu

doi:10.3389/fpubh.2023.1272149

Season of delivery and risk of venous thromboembolism during hospitalization among pregnant women

Front Public Health. 2023 Nov 8:11:1272149. doi: 10.3389/fpubh.2023.1272149. eCollection 2023.

Authors

Qian Li^#¹, Hongfei Wang^#², Huafang Wang¹, Jun Deng¹, Zhipeng Cheng¹, Wenyi Lin¹, Ruiqi Zhu¹, Shi Chen³, Jinrong Guo⁴, Huarong Li⁵, Yong Chen⁶, Xiaowei Yuan⁷, Shulan Dai⁸, Yan Tian⁹, Yanyan Xu⁹, Ping Wu¹⁰, Fan Zhang¹¹, Xiaojiang Wang¹², Liang V Tang¹, Yu Hu¹

Affiliations

¹ Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
² Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
³ Department of Biobank, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
⁴ Department of Medical Records Management and Statistics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
⁵ Department of Integrated Traditional Chinese and Western Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
⁶ Department of Obstetrics and Gynecology, Jingshan Union Hospital, Union Hospital, Huazhong University of Science and Technology, Jingshan, Hubei, China.
⁷ Department of Medical Services Division, People's Hospital of Dongxihu District Wuhan City and Union Dongxihu Hospital, Huazhong University of Science and Technology, Wuhan, Hubei, China.
⁸ Department of Obstetrics and Gynecology, People's Hospital of Dongxihu District Wuhan City and Union Dongxihu Hospital, Huazhong University of Science and Technology, Wuhan, Hubei, China.
⁹ Department of Obstetrics and Gynecology, Central Hospital of Hefeng County, Enshi, Hubei, China.
¹⁰ Department of Neurology, Central Hospital of Hefeng County, Enshi, Hubei, China.
¹¹ Department of Obstetrics and Gynecology, The Sixth General Hospital of Hubei Province, Wuhan, Hubei, China.
¹² Department of Respiratory and Critical Care Medicine, The Sixth General Hospital of Hubei Province, Wuhan, Hubei, China.

^# Contributed equally.

Abstract

Background: Seasons were found to be related to the occurrences of venous thromboembolism (VTE) in hospitalized patients. No previous study has explored whether seasons were associated with VTE risk in pregnant women. This study aimed to investigate the relationships between the season of delivery and VTE risk during hospitalization among pregnant women.

Methods: This is a multi-center retrospective cohort study of pregnant women. Participants were those who delivered at seven designated sites in Hubei Province, China, during the period from January 2017 to December 2022. They were categorized according to their season/month of delivery. Information on new-onset VTE during hospitalization was followed.

Results: Approximately 0.28% (104/37,778) of the pregnant women developed new-onset VTE during hospitalization for delivery. After adjustment, compared with participants in the spring group, participants in the summer, autumn, and winter groups had an increased risk of VTE during hospitalization. The ORs were 2.59 [1.30, 5.15], 2.83 [1.43, 5.60], and 2.35 [1.17, 4.75] for the summer, autumn, and winter groups, respectively. Pregnant women in the combined group (summer + autumn + winter) had an increased risk of VTE during hospitalization than those in the spring group (OR, 2.59 [1.39, 4.85]). By restricting the analyses among pregnant women without in vitro fertilization, gestational diabetes mellitus, and preterm, the results still remained robust. Compared with participants who delivered in March, April, and May, participants who delivered in June, July, September, November, December, and February had a higher risk of VTE during hospitalization.

Conclusion: This study demonstrated that pregnant women who delivered in summer, autumn, and winter had an increased VTE risk during hospitalization compared with those who delivered in spring.

Keywords: GDM; IVF; pregnant women; season; venous thromboembolism.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Female
Hospitalization
Humans
Infant, Newborn
Pregnancy
Pregnant Women
Retrospective Studies
Seasons
Venous Thromboembolism* / epidemiology

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This study is supported by the National Natural Science Foundation of China (No. 81973995, No. 82170131 and No. 82103827), and the Young Top-notch Talent Cultivation Program of Hubei Province 202117.