Engineered Extracellular Vesicles: A potential treatment for regeneration

Wen Cheng; Chenyu Xu; Yuran Su; Youqing Shen; Qiang Yang; Yanmei Zhao; Yanhong Zhao; Yue Liu

doi:10.1016/j.isci.2023.108282

Engineered Extracellular Vesicles: A potential treatment for regeneration

iScience. 2023 Oct 24;26(11):108282. doi: 10.1016/j.isci.2023.108282. eCollection 2023 Nov 17.

Authors

Wen Cheng¹, Chenyu Xu¹, Yuran Su¹, Youqing Shen¹, Qiang Yang², Yanmei Zhao³, Yanhong Zhao¹, Yue Liu²

Affiliations

¹ Department of Orthodontics, School and Hospital of Stomatology, Tianjin Medical University, Tianjin 300070, China.
² Department of Orthopedics, Tianjin University Tianjin Hospital, Tianjin University, Tianjin 300211, China.
³ Institute of Disaster and Emergency Medicine, Tianjin University, Tianjin 300072, China.

Abstract

Extracellular vesicles (EVs) play a critical role in various physiological and pathological processes. EVs have gained recognition in regenerative medicine due to their biocompatibility and low immunogenicity. However, the practical application of EVs faces challenges such as limited targeting ability, low yield, and inadequate therapeutic effects. To overcome these limitations, engineered EVs have emerged. This review aims to comprehensively analyze the engineering methods utilized for modifying donor cells and EVs, with a focus on comparing the therapeutic potential between engineered and natural EVs. Additionally, it aims to investigate the specific cell effects that play a crucial role in promoting repair and regeneration, while also exploring the underlying mechanisms involved in the field of regenerative medicine.

Keywords: Bioengineering; Biological sciences; Cell biology.

Publication types

Review