Temporal bright light at low frequency retards lens-induced myopia in guinea pigs

Baodi Deng; Wentao Li; Ziping Chen; Junwen Zeng; Feng Zhao

doi:10.7717/peerj.16425

Temporal bright light at low frequency retards lens-induced myopia in guinea pigs

PeerJ. 2023 Nov 14:11:e16425. doi: 10.7717/peerj.16425. eCollection 2023.

Authors

Baodi Deng^#¹, Wentao Li^#², Ziping Chen³, Junwen Zeng¹, Feng Zhao¹

Affiliations

¹ State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China.
² Huizhou Third People's Hospital, Guangzhou Medical University, Huizhou, China.
³ Guangdong Light Visual Health Research Institute, Guangzhou, China.

^# Contributed equally.

Abstract

Purpose: Bright light conditions are supposed to curb eye growth in animals with experimental myopia. Here we investigated the effects of temporal bright light at very low frequencies exposures on lens-induced myopia (LIM) progression.

Methods: Myopia was induced by application of -6.00 D lenses over the right eye of guinea pigs. They were randomly divided into four groups based on exposure to different lighting conditions: constant low illumination (CLI; 300 lux), constant high illumination (CHI; 8,000 lux), very low frequency light (vLFL; 300/8,000 lux, 10 min/c), and low frequency light (LFL; 300/8,000 lux, 20 s/c). Refraction and ocular dimensions were measured per week. Changes in ocular dimensions and refractions were analyzed by paired t-tests, and differences among the groups were analyzed by one-way ANOVA.

Results: Significant myopic shifts in refractive error were induced in lens-treated eyes compared with contralateral eyes in all groups after 3 weeks (all P < 0.05). Both CHI and LFL conditions exhibited a significantly less refractive shift of LIM eyes than CLI and vLFL conditions (P < 0.05). However, only LFL conditions showed significantly less overall myopic shift and axial elongation than CLI and vLFL conditions (both P < 0.05). The decrease in refractive error of both eyes correlated significantly with axial elongation in all groups (P < 0.001), except contralateral eyes in the CHI group (P = 0.231). LFL condition significantly slacked lens thickening in the contralateral eyes.

Conclusions: Temporal bright light at low temporal frequency (0.05 Hz) appears to effectively inhibit LIM progression. Further research is needed to determine the safety and the potential mechanism of temporal bright light in myopic progression.

Keywords: Dynamic light; Guinea pigs; Lens-induced myopia; Temporal illumination modulation.

MeSH terms

Animals
Eye
Guinea Pigs
Lighting*
Myopia* / prevention & control
Refraction, Ocular
Refractive Errors

Associated data

figshare/10.6084/m9.figshare.23708685.v1

Grants and funding

This work was supported by the Science and Technology Planning Project of Guangdong Province (2016A040403016); the Science and Technology Project of Guangzhou (202102020886); and the China Educational Equipment Industry Association (CEFR20001K1). No funding or sponsorship was received for the publication of this article. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.