Diffuse Endocapillary Glomerulonephritis in a Child With IL-17RA Deficiency Emphasizes the Pivotal Role of the Complement Cascade and Anaphylatoxins

Affiliations

• ¹ Department of Pathology, Necker-Enfants Malades Hospital, APHP, Paris, France.
• ² Pediatric Nephrology, MARHEA Reference Center, Imagine Institute, Université Paris Cité, Necker-Enfants Malades Hospital, APHP, Paris, France.
• ³ Université Paris Cité and Sorbonne Université, INSERM UMRS 1138, Centre de Recherche des Cordeliers, Inflammation, Complement and Cancer Team, Paris, France; Department of Immunology, Assistance Publique-Hôpitaux de Paris, Hopital Européen Georges Pompidou, Paris, France.
• ⁴ Pediatric Hematology-Immunology-Rheumatology Unit, Necker-Enfants Malades Hospital, APHP, Paris, France.
• ⁵ Laboratoire de Génétique Humaine des Maladies Infectieuses, UMR1163, Imagine Institute, Paris, France.
• ⁶ Department of General Pediatrics and Pediatric Infectious Diseases, Necker-Enfants Malades Hospital, APHP, Paris, France.
• ⁷ Université Paris Cité, INSERM U1151, CNRS UMR 8253, Institut Necker Enfants Malades, Département Croissance et Signalisation, Paris, France.