Sickle cell anemia and pregnancy: Profile of hemodynamic changes in sickle cell pregnant women in Kinshasa

Tite Minga Mikobi; Nelly Ciombo Kamuanya; Emmanuelle Ketsia Bokashanga Mikobi; Thérèse Ilunga Kalela; Pierre Zalagile Akilimali; Prosper Tshilobo Lukusa

doi:10.1002/jha2.789

Sickle cell anemia and pregnancy: Profile of hemodynamic changes in sickle cell pregnant women in Kinshasa

EJHaem. 2023 Sep 11;4(4):977-983. doi: 10.1002/jha2.789. eCollection 2023 Nov.

Authors

Tite Minga Mikobi^{1

2

3}, Nelly Ciombo Kamuanya^{1

3}, Emmanuelle Ketsia Bokashanga Mikobi¹, Thérèse Ilunga Kalela⁴, Pierre Zalagile Akilimali⁵, Prosper Tshilobo Lukusa^{1

2

6}

Affiliations

¹ Centre d'Excellence de la Drépanocytose, Department of Molecular Biology and Genetics, Department of Basic Sciences, School of Medicine University of Kinshasa Kinshasa DRC.
² Center for Human Genetics, School of Medicine University of Medicine Kinshasa DRC.
³ Center of Sickle cell anemia Institut de Recherche en Sciences de la santé (IRSS) Kinshasa DRC.
⁴ Service of ecotoxicology, department of the environment, Faculty of sciences University of Kinshasa Kinshasa DRC.
⁵ Department of Epidemiology and Biostatistics, School of Public Health University of Kinshasa Kinshasa DRC.
⁶ Genetics Unit, Neonatology Service, Department of Pediatrics, University Hospital of Kinshasa University of Kinshasa Kinshasa DRC.

Abstract

Pregnancy is accompanied by hormonal changes. These relate mainly to progesterone and placenate growth factor. Hemodynamic changes are also observed. in a sickle cell pregnant woman, all these changes have a direct effect on hypoxia. This is responsible for the polymerization of HbS. The latter causes the sickling of sickle red blood cells. sickling of red blood cells is responsible for hemolysis and vasoocclusion, two major acute manifestations during pregnancy in a sickle cell patient.

Keywords: changes; hemodynamics; pregnancy; sickle cell anemia.