Single-shot OCT and OCT angiography for slab-specific detection of diabetic retinopathy

Guangru B Liang; Tristan T Hormel; Xiang Wei; Yukun Guo; Jie Wang; Thomas Hwang; Yali Jia

doi:10.1364/BOE.503476

Single-shot OCT and OCT angiography for slab-specific detection of diabetic retinopathy

Biomed Opt Express. 2023 Oct 10;14(11):5682-5695. doi: 10.1364/BOE.503476. eCollection 2023 Nov 1.

Authors

Guangru B Liang^{1

2}, Tristan T Hormel², Xiang Wei^{1

2}, Yukun Guo^{1

2}, Jie Wang^{1

2}, Thomas Hwang², Yali Jia^{1

2}

Affiliations

¹ Department of Biomedical Engineering, Oregon Health & Science University, 3303 S.W. Bond Avenue, Portland, OR 97239, USA.
² Casey Eye Institute, Oregon Health & Science University, 515 S.W. Campus Drive, Portland, OR 97239, USA.

Abstract

In this study, we present an optical coherence tomographic angiography (OCTA) prototype using a 500 kHz high-speed swept-source laser. This system can generate a 75-degree field of view with a 10.4 µm lateral resolution with a single acquisition. With this prototype we acquired detailed, wide-field, and plexus-specific images throughout the retina and choroid in eyes with diabetic retinopathy, detecting early retinal neovascularization and locating pathology within specific retinal slabs. Our device could also visualize choroidal flow and identify signs of key biomarkers in diabetic retinopathy.

Grants and funding

UL1 TR002369/TR/NCATS NIH HHS/United States